[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=7927784 [NCBI, ExPASy, EBI, Israel, Japan] Garrad R.C., Schmidt T.M., Bhattacharjee J.K.; "Molecular and functional analysis of the LYS1 gene of Candida albicans."; Infect. Immun. 62:5027-5031(1994).

Comments

CATALYTIC ACTIVITY: N⁶-(L-1,3-dicarboxypropyl)-L-lysine + NAD⁺ + H₂O = L-lysine + 2-oxoglutarate + NADH.
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungi route): step 3/3 .
SUBUNIT: Monomer (By similarity).
SIMILARITY: Belongs to the AlaDH/PNT family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U13233; AAA21362.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P43065.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0004754;	Molecular function: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity (inferred from electronic annotation from EC).
GO:0009085;	Biological process: lysine biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR007698; Ala_DHase/PNT_C.
IPR007886; Ala_DHase/PNT_N.
Graphical view of domain structure.

Pfam

PF01262; AlaDh_PNT_C; 1.
PF05222; AlaDh_PNT_N; 1.
Pfam graphical view of domain structure.

ProtoNet

P43065.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Lysine biosynthesis; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 382`	`382`	`Saccharopine dehydrogenase [NAD+, L-lysine-forming].`	`PRO_0000199010`
`ACT_SITE`	`217 217`		`By similarity.`

Sequence information

Length: 382 AA [This is the length of the unprocessed precursor]

Molecular weight: 42394 Da [This is the MW of the unprocessed precursor]

CRC64: A3620191DF04B88F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKSPVILHL RAETKPLEAR AALTPSTTKQ LLDAGFEIYV EESSQSTFDI KEYEAVGAKI 

        70         80         90        100        110        120 
VPEGSWKTAP KERIIFGLKE LPENETFPLI HEHIQFAHCY KDQAGWQDVL KRFPQGNGIL 

       130        140        150        160        170        180 
YDLEFLENDQ GRRVAAFGFY AGFAGAAIGV LDWSFKQLNG NTKGTKGEGE GGELPGVTPY 

       190        200        210        220        230        240 
PNENELIKDV KIELEKALTK NGGQYPKCLV IGALGRCGSG AIDLFKKIGI PDDNIAKWDM 

       250        260        270        280        290        300 
AETAKGGPFQ EIVDSDIFIN CIYLSKPIPP FINKEILNNE NRKLTTIVDV SADTTNPHNP 

       310        320        330        340        350        360 
IPVYEIATVF NEPTVEVKLD KGPKLSVCSI DHLPSLLPRE ASEFFAKDLM PSLLELPNRD 

       370        380 
TSPVWVRAKQ LFDKHVARLD KE

P43065 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools