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UniProtKB/Swiss-Prot entry P43067

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_CANAL
Primary accession number P43067
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen Cand a 1
Gene name
Name: ADH1
Synonyms: CAD
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1002/(SICI)1097-0061(199602)12:2<115::AID-YEA889>3.0.CO;2-E; PubMed=8686375 [NCBI, ExPASy, EBI, Israel, Japan]
Bertram G., Swoboda R.K., Gooday G.W., Gow N.A.R., Brown A.J.P.;
"Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase.";
Yeast 12:115-127(1996).
[2]
 NUCLEOTIDE SEQUENCE.
STRAIN=B311A;
Pendrak M.L., Klotz S.A., Smith R.L.;
Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE OF 104-313.
DOI=10.1111/j.1365-2222.1991.tb03195.x; PubMed=1777830 [NCBI, ExPASy, EBI, Israel, Japan]
Shen H.D., Choo K.B., Lee H.H., Hsieh J.C., Lin W.L., Lee W.R., Han S.H.;
"The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies.";
Clin. Exp. Allergy 21:675-681(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X81694; CAA57342.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U15924; AAA53300.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S63781; S52153.
3D structure databases
HSSP P39462; 1JVB. [HSSP ENTRY / PDB]
SMR P43067; 5-350.
ModBase P43067.
2D gel databases
COMPLUYEAST-2DPAGE P43067; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet P43067.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Allergen; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   350  350     Alcohol dehydrogenase 1. PRO_0000160717
METAL   46    46        Zinc 1; catalytic (By similarity). 
METAL   69    69        Zinc 1; catalytic (By similarity). 
METAL   100   100        Zinc 2 (By similarity). 
METAL   103   103        Zinc 2 (By similarity). 
METAL   106   106        Zinc 2 (By similarity). 
METAL   114   114        Zinc 2 (By similarity). 
METAL   156   156        Zinc 1; catalytic (By similarity). 
CONFLICT   39    39        H -> N (in Ref. 2; AAA53300). 
CONFLICT   53    53        R -> W (in Ref. 2; AAA53300). 
CONFLICT   140   140        A -> T (in Ref. 3). 
CONFLICT   212   212        F -> L (in Ref. 2; AAA53300). 
CONFLICT   227   227        D -> A (in Ref. 3). 
CONFLICT   313   313        R -> S (in Ref. 3). 
CONFLICT   327   327        D -> E (in Ref. 2; AAA53300). 
Sequence information
Length: 350 AA [This is the length of the unprocessed precursor] Molecular weight: 36879 Da [This is the MW of the unprocessed precursor] CRC64: C3DFE2E70F42D634 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL HARKGDWPLA 

        70         80         90        100        110        120 
TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC MSCEFCQQGA EPNCGEADLS 

       130        140        150        160        170        180 
GYTHDGSFEQ YATADAVQAA KIPAGTDLAN VAPILCAGVT VYKALKTADL AAGQWVAISG 

       190        200        210        220        230        240 
AGGGLGSLAV QYARAMGLRV VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG 

       250        260        270        280        290        300 
GPHGAINVSV SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN 

       310        320        330        340        350 
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK
P43067 in FASTA format

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