ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P43304


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GPDM_HUMAN
Primary accession number P43304
Secondary accession numbers Q59FR1 Q9HAP9
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on February 7, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 82)
Name and origin of the protein
Protein name Glycerol-3-phosphate dehydrogenase, mitochondrial [Precursor]
Synonyms GPDH-M
GPD-M
EC 1.1.99.5
mtGPD
Gene name
Name: GPD2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT HIS-525.
DOI=10.1016/0378-1119(94)90469-3; PubMed=7821823 [NCBI, ExPASy, EBI, Israel, Japan]
Lehn D.A., Brown L.J., Simonson G.D., Moran S.M., McDonald M.J.;
"The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA.";
Gene 150:417-418(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8549872 [NCBI, ExPASy, EBI, Israel, Japan]
Ferrer J., Aoki M., Behn P., Nestorowicz A., Riggs A., Permutt M.A.;
"Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker.";
Diabetes 45:262-266(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(96)00019-4; PubMed=8682323 [NCBI, ExPASy, EBI, Israel, Japan]
Brown L.J., Stoffel M., Moran S.M., Fernald A.A., Lehn D.A., LeBeau M.M., MacDonald M.J.;
"Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene.";
Gene 172:309-312(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT HIS-525.
TISSUE=Testis;
Yin L.L., Li J.M., Sha J.H.;
"A novel glycerol-3-phosphate dehydrogenase 3 from adult testis.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno F.R.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-408.
TISSUE=Brain;
PubMed=9110174 [NCBI, ExPASy, EBI, Israel, Japan]
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
"Large-scale concatenation cDNA sequencing.";
Genome Res. 7:353-358(1997).
[7]
PROTEIN SEQUENCE OF 212-227 AND 558-572, AND MASS SPECTROMETRY.
TISSUE=Brain, and Cajal-Retzius cell;
Lubec G., Afjehi-Sadat L.;
Submitted (MAR-2007) to UniProtKB.
[8]
PROTEIN SEQUENCE OF 340-348; 410-418; 526-538; 558-572 AND 715-722, AND MASS SPECTROMETRY.
TISSUE=Platelet;
Bienvenut W.V., Claeys D.;
Submitted (JAN-2006) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U12424; AAA65701.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U36310; AAB60403.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40367; AAC50556.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40353; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40354; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40355; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40357; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40358; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40359; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40360; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40361; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40362; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40363; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40364; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U40365; AAC50556.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF311325; AAG33851.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209399; BAD92636.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U79250; AAB50200.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G02093; G02093.
RefSeq NP_000399.2; -.
NP_001076581.1; -.
UniGene Hs.512382
3D structure databases
HSSP P02593; 1CTR. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase P43304.
PTM databases
PhosphoSite P43304; -.
2D gel databases
REPRODUCTION-2DPAGE IPI00017895; -.
Organism-specific databases
HGNC HGNC:4456; GPD2.
GenAtlas GPD2.
HPA HPA008012; -.
MIM 138430; gene. [NCBI / EBI]
PharmGKB PA28837; -.
GeneCards P43304.
Gene expression databases
ArrayExpress P43304; -.
CleanEx HS_GPD2; -.
GermOnline ENSG00000115159; Homo sapiens.
Ontologies
GO
GO:0009331; Cellular component: glycerol-3-phosphate dehydrogenase complex (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (traceable author statement from ProtInc).
GO:0004368; Molecular function: glycerol-3-phosphate dehydrogenase activity (traceable author statement from ProtInc).
GO:0006072; Biological process: glycerol-3-phosphate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011992; EF-Hand_type.
IPR002048; EF_hand_Ca_bd.
IPR000447; FAD-dep_Gly3P_DHase.
IPR006076; FAD-dep_OxRdtase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.238.10; EF-Hand_type; 1.
Pfam PF01266; DAO; 1.
PF00036; efhand; 2.
Pfam graphical view of domain structure.
PRINTS PR01001; FADG3PDH.
ProDom PD000012; EF-hand; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00054; EFh; 2.
SMART graphical view of domain structure.
PROSITE PS00018; EF_HAND_1; 1.
PS50222; EF_HAND_2; 2.
PS00977; FAD_G3PDH_1; 1.
PS00978; FAD_G3PDH_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P43304.
Genome annotation databases
Ensembl ENSG00000115159; Homo sapiens. [Contig view]
GeneID 2820; -.
KEGG hsa:2820; -.
Phylogenomic databases
HOGENOM P43304; -.
HOVERGEN P43304; -.
Other
LinkHub P43304; -.
NextBio 11111; -.
SOURCE GPD2; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Calcium; Direct protein sequencing; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Repeat; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    42  42     Mitochondrion (By similarity). 
CHAIN   43   727  685     Glycerol-3-phosphate dehydrogenase, mitochondrial. PRO_0000010429
DOMAIN   623   658  36     EF-hand 1. 
DOMAIN   659   694  36     EF-hand 2. 
NP_BIND   71    99  29     FAD (Potential). 
CA_BIND   672   683  12     Potential. 
MOD_RES   600   600        Phosphotyrosine (By similarity). 
MOD_RES   601   601        Phosphotyrosine (By similarity). 
VAR_SEQ   1   126        Missing (in isoform 2). VSP_017134
VARIANT   525   525  1     R -> H (in dbSNP:rs1051916 [NCBI]). VAR_025215 
Sequence information
Length: 727 AA [This is the length of the unprocessed precursor] Molecular weight: 80834 Da [This is the MW of the unprocessed precursor] CRC64: 2D6A7F02D32E634A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAFQKAVKGT ILVGGGALAT VLGLSQFAHY RRKQMNLAYV KAADCISEPV NREPPSREAQ 

        70         80         90        100        110        120 
LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR 

       130        140        150        160        170        180 
YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI MLPVYKWWQL PYYWVGIKLY 

       190        200        210        220        230        240 
DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG 

       250        260        270        280        290        300 
AATANYMEVV SLLKKTDPQT GKVHVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM 

       310        320        330        340        350        360 
DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD 

       370        380        390        400        410        420 
VTHHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTQSISRNH 

       430        440        450        460        470        480 
VVDISESGLI TIAGGKWTTY RSMAEDTINA AVKTHNLKAG PSRTVGLFLQ GGKDWSPTLY 

       490        500        510        520        530        540 
IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG 

       550        560        570        580        590        600 
IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDYKKQE QLETARKFLY 

       610        620        630        640        650        660 
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADQK GFITIVDVQR VLESINVQMD 

       670        680        690        700        710        720 
ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV 


DRSCGGL 

P43304 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!