ID   AL3B1_HUMAN             Reviewed;         468 AA.
AC   P43353; Q53XL5; Q8N515; Q96CK8;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 77.
DE   RecName: Full=Aldehyde dehydrogenase family 3 member B1;
DE            EC=1.2.1.5;
DE   AltName: Full=Aldehyde dehydrogenase 7;
GN   Name=ALDH3B1; Synonyms=ALDH7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Kidney;
RX   MEDLINE=95129876; PubMed=7828891; DOI=10.1016/0378-1119(94)90672-6;
RA   Hsu L.C., Chang W.-C., Yoshida A.;
RT   "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde
RT   dehydrogenase family.";
RL   Gene 151:285-289(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Lung, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-368, AND MASS
RP   SPECTROMETRY.
RX   PubMed=18187866; DOI=10.2116/analsci.24.161;
RA   Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
RT   "Automated phosphoproteome analysis for cultured cancer cells by two-
RT   dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
RL   Anal. Sci. 24:161-166(2008).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = an acid +
CC       NAD(P)H.
CC   -!- PATHWAY: Alcohol metabolism; ethanol degradation; acetate from
CC       ethanol: step 2/2.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P43353-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P43353-2; Sequence=VSP_014040;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Highest expression in kidney and lung.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; U10868; AAA83428.1; -; mRNA.
DR   EMBL; BT009832; AAP88834.1; -; mRNA.
DR   EMBL; BC013584; AAH13584.1; -; mRNA.
DR   EMBL; BC014168; AAH14168.2; -; mRNA.
DR   EMBL; BC033099; AAH33099.1; -; mRNA.
DR   PIR; I38669; I38669.
DR   RefSeq; NP_000685.1; -.
DR   RefSeq; NP_001025181.1; -.
DR   UniGene; Hs.523841; -.
DR   HSSP; P11883; 1AD3.
DR   PhosphoSite; P43353; -.
DR   Ensembl; ENSG00000006534; Homo sapiens.
DR   GeneID; 221; -.
DR   KEGG; hsa:221; -.
DR   HGNC; HGNC:410; ALDH3B1.
DR   MIM; 600466; gene.
DR   PharmGKB; PA24699; -.
DR   HOGENOM; P43353; -.
DR   HOVERGEN; P43353; -.
DR   DrugBank; DB00157; NADH.
DR   NextBio; 894; -.
DR   ArrayExpress; P43353; -.
DR   CleanEx; HS_ALDH3B1; -.
DR   GermOnline; ENSG00000006534; Homo sapiens.
DR   GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; TAS:ProtInc.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; TAS:ProtInc.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; TAS:ProtInc.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR012394; Ald_DHase_NAD(P).
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   PANTHER; PTHR11699:SF15; ALDH; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; NAD; Oxidoreductase; Phosphoprotein.
FT   CHAIN         1    468       Aldehyde dehydrogenase family 3 member
FT                                B1.
FT                                /FTId=PRO_0000056481.
FT   NP_BIND     188    193       NAD (By similarity).
FT   ACT_SITE    210    210       By similarity.
FT   ACT_SITE    244    244       By similarity.
FT   MOD_RES     368    368       Phosphoserine.
FT   VAR_SEQ      55     91       Missing (in isoform 2).
FT                                /FTId=VSP_014040.
SQ   SEQUENCE   468 AA;  51840 MW;  30BEEB982395D2F7 CRC64;
     MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE
     VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL
     TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR
     FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA
     GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC
     GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK
     PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD
     TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL
//