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UniProtKB/Swiss-Prot entry P43788

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TRXB_HAEIN
Primary accession number P43788
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Thioredoxin reductase
Synonyms TRXR
EC 1.8.1.9
Gene name
Name: trxB
OrderedLocusNames: HI1158
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22813.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G64186; G64186.
RefSeq NP_439316.1; -.
3D structure databases
HSSP P09625; 1TRB. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR P43788; 5-315.
ModBase P43788.
Enzyme and pathway databases
BioCyc HINF71421:HI_1158-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0004791; Molecular function: thioredoxin-disulfide reductase activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019430; Biological process: removal of superoxide radicals (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000759; Adrndx_reductase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR008255; Pyr_nucl-diS_OxRdtase_2_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
IPR005982; Thioredox_reduct.
Graphical view of domain structure.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01292; TRX_reduct; 1.
PROSITE PS00573; PYRIDINE_REDOX_2; 1.
ProtoNet P43788.
Genome annotation databases
GeneID 950118; -.
GenomeReviews L42023_GR; HI1158.
KEGG hin:HI1158; -.
NMPDR fig|71421.1.peg.1111; -.
TIGR HI1158; -.
Phylogenomic databases
HOGENOM P43788; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   318  318     Thioredoxin reductase. PRO_0000166732
NP_BIND   36    43  8     FAD (By similarity). 
NP_BIND   286   295  10     FAD (By similarity). 
DISULFID   136   139        Redox-active (By similarity). 
Sequence information
Length: 318 AA [This is the length of the unprocessed precursor] Molecular weight: 34395 Da [This is the MW of the unprocessed precursor] CRC64: 2BAEBC5DDE6020AA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSDIKHAKLL ILGSGPAGYT AAIYAARANL KPVLVTGLQQ GGQLTTTDEI ENWPGDFEMT 

        70         80         90        100        110        120 
TGSGLMQRML QHAEKFETEI VFDHINRVDL SSRPFKLFGD VQNFTCDALI IATGASARYI 

       130        140        150        160        170        180 
GLPSEENYKG RGVSACATCD GFFYRNKPVG VIGGGNTAVE EALYLANIAS TVHLIHRRDS 

       190        200        210        220        230        240 
FRAEKILIDR LYKKVEEGKI VLHTDRTLDE VLGDNMGVTG LRLANTKTGE KEELKLDGLF 

       250        260        270        280        290        300 
VAIGHSPNTE IFQGQLELNN GYIVVKSGLD GNATATSVEG VFAAGDVMDH NYRQAITSAG 

       310 
TGCMAALDAE RYLDAQEA
P43788 in FASTA format

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