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UniProtKB/Swiss-Prot entry P43837

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO2_HAEIN
Primary accession number P43837
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name NADP-dependent malic enzyme
Synonyms NADP-ME
EC 1.1.1.40
Gene name
Name: maeB
OrderedLocusNames: HI1245
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22896.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR F64112; F64112.
RefSeq NP_439401.1; -.
3D structure databases
ModBase P43837.
Enzyme and pathway databases
BioCyc HINF71421:HI_1245-MON; -.
Ontologies
GO
GO:0008415; Molecular function: acyltransferase activity (inferred from electronic annotation from InterPro).
GO:0004473; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity (inferred from electronic annotation from EC).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR012188; ME_PTA.
IPR016040; NAD(P)-bd.
IPR002505; PTA_PTB.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
PF01515; PTA_PTB; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036684; ME_PTA; 1.
PROSITE PS00331; MALIC_ENZYMES; 1.
ProtoNet P43837.
Genome annotation databases
GeneID 949562; -.
GenomeReviews L42023_GR; HI1245.
KEGG hin:HI1245; -.
NMPDR fig|71421.1.peg.1191; -.
TIGR HI1245; -.
Phylogenomic databases
HOGENOM P43837; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; Multifunctional enzyme; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   756  756     NADP-dependent malic enzyme. PRO_0000160243
NP_BIND   76    83  8     NADP (By similarity). 
REGION   1   428  428     Malic enzyme. 
REGION   429   756  328     Phosphate acetyltransferase. 
ACT_SITE   94    94        Proton acceptor (By similarity). 
METAL   136   136        Divalent metal cation (By similarity). 
METAL   137   137        Divalent metal cation (By similarity). 
BINDING   162   162        NAD (By similarity). 
BINDING   288   288        NAD (By similarity). 
Sequence information
Length: 756 AA [This is the length of the unprocessed precursor] Molecular weight: 81880 Da [This is the MW of the unprocessed precursor] CRC64: 8D303736F08B8E3B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTEQLRQAAL DFHEFPIPGK IEVTPTKSLA TQRDLALAYS PGVAEPCLEI EKDPAASYKY 

        70         80         90        100        110        120 
TARGNLVAVI SNGTAVLGLG NIGALAGKPV MEGKGVLFKK FAGINVFDIE VNEHDPDKLV 

       130        140        150        160        170        180 
DIIASLEPTF GGVNLEDIKA PECFYIEQKL RERMNIPVFH DDQHGTAIIS AAAIINSLRI 

       190        200        210        220        230        240 
VGKKIEDVRL VASGAGAASI ACLNLLLSLG MKRENITVCD SKGVVYKGRD DKMDQTKKEY 

       250        260        270        280        290        300 
AIEDNGWRKL ADAIPNADIF LGCSAAGALT QDMVKSMAAH PIILALANPN PEITPPEAKA 

       310        320        330        340        350        360 
VRPDAIVCTG RSDYPNQVNN VLCFPFIFRG ALDVGATTIN EEMKRAAVYA IADLALEEQN 

       370        380        390        400        410        420 
EVVTSAYGGE GATFGADYVI PRPFDPRLIV RIAPAVAKAA MESGVATRPI QNWDAYVEKL 

       430        440        450        460        470        480 
TQFVYKTSLF MRPIFSQAKS AKQRIILAEG EENKALHATQ EVISMGLANP ILIGRRSVIE 

       490        500        510        520        530        540 
EKIKKLGLRL TAGVDFEIVD NEDNPRYEEC WKHYYELTKR KGITPAIAKR VVRSNTTVLA 

       550        560        570        580        590        600 
STLLSLGYAD ALVCGLFGSY GKHLASIRDI IGLKDGVKTA AALNSLVLPT GNVFLTDTHV 

       610        620        630        640        650        660 
NSNPTAEELA EITLMAAEEI HRFGIEPAVA LLSHSNFGSS DSLGAPKMRE VLQIVKERNP 

       670        680        690        700        710        720 
HLMIDGEMRG DLAMNEAHRK ELMPDSPLKG SANLLVFPDL SASRISYSLL RGTTTAITVG 

       730        740        750 
PILMGMNKSA HILNPGASVR RIINMIAYAA VKAQQE
P43837 in FASTA format

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