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UniProtKB/Swiss-Prot entry P43842

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PNTA_HAEIN
Primary accession number P43842
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name NAD(P) transhydrogenase subunit alpha
Synonyms EC 1.6.1.2
Nicotinamide nucleotide transhydrogenase subunit alpha
Pyridine nucleotide transhydrogenase subunit alpha
Gene name
Name: pntA
OrderedLocusNames: HI1362
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC23009.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E64119; E64119.
RefSeq NP_439513.1; -.
3D structure databases
HSSP Q60164; 1L7E. [HSSP ENTRY / PDB]
SMR P43842; 3-375.
ModBase P43842.
Enzyme and pathway databases
BioCyc HINF71421:HI_1362-MON; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0008750; Molecular function: NAD(P)+ transhydrogenase (AB-specific) activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR007698; Ala_DHase/PNT_C.
IPR008142; Ala_DHase/PNT_CS1.
IPR008143; Ala_DHase/PNT_CS2.
IPR007886; Ala_DHase/PNT_N.
IPR016040; NAD(P)-bd.
IPR004571; NADP_transhyd_a.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01262; AlaDh_PNT_C; 1.
PF05222; AlaDh_PNT_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00561; pntA; 1.
PROSITE PS00836; ALADH_PNT_1; 1.
PS00837; ALADH_PNT_2; 1.
ProtoNet P43842.
Genome annotation databases
GeneID 950278; -.
GenomeReviews L42023_GR; HI1362.
KEGG hin:HI1362; -.
NMPDR fig|71421.1.peg.1298; -.
TIGR HI1362; -.
Phylogenomic databases
HOGENOM P43842; -.
Other
LinkHub P43842; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   512  512     NAD(P) transhydrogenase subunit alpha. PRO_0000199018
TRANSMEM   401   421  21     Potential. 
TRANSMEM   422   442  21     Potential. 
TRANSMEM   452   472  21     Potential. 
TRANSMEM   479   499  21     Potential. 
NP_BIND   167   197  31     NAD (By similarity). 
Sequence information
Length: 512 AA [This is the length of the unprocessed precursor] Molecular weight: 54973 Da [This is the MW of the unprocessed precursor] CRC64: 50D63AD536E837EF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLIGVPRELL ENESRVAATP KTVQQILKLG FDVIVEHDAG FKASFEDQAF LEAGAKIGTS 

        70         80         90        100        110        120 
AEIWQSDIIF KVNAPTDEEI AQMKEGAALV SFIWRMQNPE LMKKLTAKKI NVLAMDAVPR 

       130        140        150        160        170        180 
ISRAQALDAL SSMANISGYR AVIEAAHEFG SFFTGQITAA GKVPPAKVLV IGAGVAGLAA 

       190        200        210        220        230        240 
IGAANSLGAI VRAFDSRPEV KEQVQSMGAS FLEIDFKEEG GSGDGYAKVM SEEFNRRAME 

       250        260        270        280        290        300 
LYAEQAKEVD IIITTAAIPG KPAPRLITKE MVDSMKPGSV IVDLAAATGG NCEYTQAGKV 

       310        320        330        340        350        360 
VTTENQVKVI GYTDFPSRLP TQSSQLYGTN LVNLLKLLCK EKDGNINIDF EDVVLRGVTV 

       370        380        390        400        410        420 
VRDGEEIPPA QIQVSAQPKQ ETKAAPVAEK KESKPTDPRV KYGVMAGVGV LFLWLASVAP 

       430        440        450        460        470        480 
AAFLSHFTVF VLACVVGYYV VWNVSHALHT PLMAVTNAIS GIIIVGALLQ IRQPTGNLFI 

       490        500        510 
DALAFVAILV ASINIFGGFR VTQRMLAMFR KG
P43842 in FASTA format

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