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UniProtKB/Swiss-Prot entry P44311

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_HAEIN
Primary accession number P44311
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 61)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf
OrderedLocusNames: HI0558
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22213.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E64077; E64077.
RefSeq NP_438715.1; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase P44311.
Enzyme and pathway databases
BioCyc HINF71421:HI_0558-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0006006; Biological process: glucose metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
ProtoNet P44311.
Genome annotation databases
GeneID 949608; -.
GenomeReviews L42023_GR; HI0558.
KEGG hin:HI0558; -.
NMPDR fig|71421.1.peg.528; -.
TIGR HI0558; -.
Phylogenomic databases
HOGENOM P44311; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   494  494     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068122
ACT_SITE   242   242        Proton acceptor (By similarity). 
BINDING   14    14        NADP (By similarity). 
BINDING   46    46        NADP (By similarity). 
BINDING   180   180        Substrate (By similarity). 
BINDING   184   184        Substrate (By similarity). 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 56189 Da [This is the MW of the unprocessed precursor] CRC64: 142F81FFB87FBADF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQTDNNCIVI FGASGDLTHR KLIPALYNLY KIGRLSENFS VLGVARSDLN DETFREKMRE 

        70         80         90        100        110        120 
ALIHNEETTP ETLDAFCSHL YYQAVNTSDA QDYGKLVPRL DDLHDKYQTC GNTFYYMSTP 

       130        140        150        160        170        180 
PSLYGVIPEC LAAHGLNTEE YGWKRIIVEK PFGYDEKTAQ TLDVQIHRFF EEHQIYRIDH 

       190        200        210        220        230        240 
YLGKETVQNL LVLRFSNGWF EPLWNRNFID YVEITGAESI GVEERGGYYD GSGAMRDMFQ 

       250        260        270        280        290        300 
NHLLQVLAMV AMEPPAIINA NSMRDEVAKV MHSLRPLTSE DMENNLVLGQ YTAAEINGKM 

       310        320        330        340        350        360 
EKGYLEEKGV PANSRTETYI ALRCEIENWR WAGVPFYVRT GKRLPARVTE IVIHFKTTPH 

       370        380        390        400        410        420 
PVFSQNAPEN KLIIRIQPDE AISMRFGLKK PGAGFEAKEV SMDFRYADLA GAQVLTAYER 

       430        440        450        460        470        480 
LLLDAMKGDA TLFARTDAVH AAWKFVQPIL DYKANGGRIH EYEAGTWGPV AADKLIAKQG 

       490 
KVWRKPSGLM KKKV
P44311 in FASTA format

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