ID   CATA_HAEIN              Reviewed;         508 AA.
AC   P44390;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 61.
DE   RecName: Full=Catalase;
DE            EC=1.11.1.6;
GN   Name=katA; Synonyms=hktE; OrderedLocusNames=HI0928;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   MEDLINE=94245618; PubMed=8188593;
RA   Bishai W.R., Smith H.O., Barcak G.J.;
RT   "A peroxide/ascorbate-inducible catalase from Haemophilus influenzae
RT   is homologous to the Escherichia coli katE gene product.";
RL   J. Bacteriol. 176:2914-2921(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   MEDLINE=95350630; PubMed=7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Decomposes hydrogen peroxide into water and oxygen;
CC       serves to protect cells from the toxic effects of hydrogen
CC       peroxide.
CC   -!- CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.
CC   -!- COFACTOR: Heme group.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- INDUCTION: By hydrogen peroxide.
CC   -!- SIMILARITY: Belongs to the catalase family.
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DR   EMBL; U02682; AAA20441.1; -; Genomic_DNA.
DR   EMBL; L42023; AAC22587.1; -; Genomic_DNA.
DR   PIR; D64103; D64103.
DR   RefSeq; NP_439088.1; -.
DR   HSSP; P42321; 1M85.
DR   GeneID; 949926; -.
DR   GenomeReviews; L42023_GR; HI0928.
DR   KEGG; hin:HI0928; -.
DR   NMPDR; fig|71421.1.peg.894; -.
DR   TIGR; HI0928; -.
DR   HOGENOM; P44390; -.
DR   BioCyc; HINF71421:HI_0928-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002226; Catalase.
DR   InterPro; IPR011614; Catalase_N.
DR   Gene3D; G3DSA:2.40.180.10; Catalase_N; 1.
DR   PANTHER; PTHR11465; Catalase; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   PRINTS; PR00067; CATALASE.
DR   ProDom; PD000510; Catalase; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Heme; Hydrogen peroxide; Iron;
KW   Metal-binding; Oxidoreductase; Peroxidase.
FT   CHAIN         1    508       Catalase.
FT                                /FTId=PRO_0000084986.
FT   ACT_SITE     63     63       By similarity.
FT   ACT_SITE    136    136       By similarity.
FT   METAL       346    346       Iron (heme axial ligand) (By similarity).
FT   CONFLICT    357    357       N -> C (in Ref. 1; AAA20441).
FT   CONFLICT    384    384       N -> T (in Ref. 1; AAA20441).
FT   CONFLICT    413    413       N -> S (in Ref. 1; AAA20441).
FT   CONFLICT    423    423       N -> T (in Ref. 1; AAA20441).
SQ   SEQUENCE   508 AA;  57680 MW;  4FAFC16DB44043B0 CRC64;
     MSSQCPFSHL AATNLTMGNG APVADNQNSL TAGPRGPLLA QDLWLNEKLA DFVREVIPER
     RMHAKGSGAF GTFTVTHDIT KYTRAKIFSE VGKKTEMFAR FTTVAGERGA ADAERDIRGF
     ALKFYTEEGN WDLVGNNTPV FFLRDPRKFP DLNKAVKRDP RTNMRSATNN WDFWTLLPEA
     LHQVTVVMSD RGIPASYRHM HGFGSHTYSF WNEAGERFWV KFHFRTQQGI KNLTDAEAAE
     IIANDRESHQ RDLYEAIERG DFPKWTLFVQ IMPEADAEKV PYHPFDLTKV WSKKDYPLIE
     VGEFELNRNP ENFFADVEQS AFAPSNLVPG IGASPDRMLQ ARLFNYADAQ RYRLGVNYRQ
     IPVNRPRCPV HSNQRDGQGR VDGNYGSLPH YEPNSFSQWQ QQPDFAEPPL RINGDAAHWD
     YRNDDNDYFS QPRALFNLMN AEQKQSLFNN TAAAMGDAPD FIKYRHIRNC HWCDAAYGEG
     VAKALGLTVE DALKARDTDP ALGQGGLL
//