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UniProtKB/Swiss-Prot entry P44638


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LGUL_HAEIN
Primary accession number P44638
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Lactoylglutathione lyase
Synonyms EC 4.4.1.5
Methylglyoxalase
Aldoketomutase
Glyoxalase I
Glx I
Ketone-aldehyde mutase
S-D-lactoylglutathione methylglyoxal lyase
Gene name
Name: gloA
OrderedLocusNames: HI0323
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
[2]
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=9719565 [NCBI, ExPASy, EBI, Israel, Japan]
Fountoulakis M., Juranville J.-F., Roeder D., Evers S., Berndt P., Langen H.;
"Reference map of the low molecular mass proteins of Haemophilus influenzae.";
Electrophoresis 19:1819-1827(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC21986.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I64147; I64147.
RefSeq NP_438488.1; -.
3D structure databases
HSSP Q59384; 1F9Z. [HSSP ENTRY / PDB]
SMR P44638; 1-125.
ModBase P44638.
Enzyme and pathway databases
BioCyc HINF71421:HI_0323-MON; -.
Ontologies
GO
GO:0004462; Molecular function: lactoylglutathione lyase activity (inferred from electronic annotation from InterPro).
GO:0016151; Molecular function: nickel ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004360; Glyas_bleo-R_dOase.
IPR004361; Glyoxalase_1.
Graphical view of domain structure.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
ProDom PD002334; Gly_diox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00068; glyox_I; 1.
PROSITE PS00934; GLYOXALASE_I_1; 1.
PS00935; GLYOXALASE_I_2; 1.
ProtoNet P44638.
Genome annotation databases
GeneID 949438; -.
GenomeReviews L42023_GR; HI0323.
KEGG hin:HI0323; -.
TIGR HI0323; -.
Phylogenomic databases
HOGENOM P44638; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Lyase; Metal-binding; Nickel.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   135  135     Lactoylglutathione lyase. PRO_0000168093
METAL   5     5        Nickel (By similarity). 
METAL   56    56        Nickel (By similarity). 
METAL   74    74        Nickel (By similarity). 
METAL   122   122        Nickel (By similarity). 
Sequence information
Length: 135 AA [This is the length of the unprocessed precursor] Molecular weight: 14893 Da [This is the MW of the unprocessed precursor] CRC64: B6DF5FFCD9669E80 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQILHTMLRV GDLDRSIKFY QDVLGMRLLR TSENPEYKYT LAFLGYEDGE SAAEIELTYN 

        70         80         90        100        110        120 
WGVDKYEHGT AYGHIAIGVD DIYATCEAVR ASGGNVTREA GPVKGGSTVI AFVEDPDGYK 

       130 
IEFIENKSTK SGLGN 

P44638 in FASTA format

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