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UniProtKB/Swiss-Prot entry P45017

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NRFA_HAEIN
Primary accession number P45017
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 78)
Name and origin of the protein
Protein name Cytochrome c-552 [Precursor]
Synonyms EC 1.7.2.2
Ammonia-forming cytochrome c nitrite reductase
Cytochrome c nitrite reductase
Gene name
Name: nrfA
OrderedLocusNames: HI1069
From
Haemophilus influenzae [TaxID: 727] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
PubMed=7542800 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.";
Science 269:496-512(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42023; AAC22727.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C64181; C64181.
RefSeq NP_439227.3; -.
3D structure databases
HSSP P32050; 1GU6. [HSSP ENTRY / PDB]
ModBase P45017.
Enzyme and pathway databases
BioCyc HINF71421:HI_1069-MON; -.
Ontologies
GO
GO:0042597; Cellular component: periplasmic space (inferred from electronic annotation from HAMAP).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042279; Molecular function: nitrite reductase (cytochrome, ammonia-forming) activity (inferred from electronic annotation from HAMAP).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006807; Biological process: nitrogen compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01182; -; 1.
PBIL [Tree]
InterPro IPR003321; Cyt_c552.
IPR017570; Cytc_552_NO2Rdtase_formate-dep.
IPR011031; Multihaem_cyt.
Graphical view of domain structure.
Pfam PF02335; Cytochrom_C552; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000243; Cyt_c552; 1.
PROSITE PS51008; MULTIHEME_CYTC; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P45017.
Genome annotation databases
GeneID 950047; -.
GenomeReviews L42023_GR; HI1069.
KEGG hin:HI1069; -.
NMPDR fig|71421.1.peg.1028; -.
TIGR HI1069; -.
Phylogenomic databases
HOGENOM P45017; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Complete proteome; Electron transport; Heme; Iron; Metal-binding; Oxidoreductase; Periplasm; Signal; Transport.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    55  55     Potential. 
CHAIN   56   538  483     Cytochrome c-552. PRO_0000006579
METAL   133   133        Iron (heme 3 axial ligand) (By similarity). 
METAL   165   165        Iron (heme 1 axial ligand) (By similarity). 
METAL   203   203        Iron (heme 2 axial ligand) (By similarity). 
METAL   268   268        Iron (heme 3 axial ligand) (By similarity). 
METAL   270   270        Calcium (By similarity). 
METAL   271   271        Calcium; via carbonyl oxygen (By similarity). 
METAL   316   316        Calcium; via carbonyl oxygen (By similarity). 
METAL   318   318        Calcium (By similarity). 
METAL   330   330        Iron (heme 5 axial ligand) (By similarity). 
METAL   341   341        Iron (heme 4 axial ligand) (By similarity). 
METAL   356   356        Iron (heme 2 axial ligand) (By similarity). 
METAL   373   373        Iron (heme 5 axial ligand) (By similarity). 
METAL   448   448        Iron (heme 4 axial ligand) (By similarity). 
BINDING   161   161        Heme 1 (covalent) (By similarity). 
BINDING   164   164        Heme 1 (covalent) (By similarity). 
BINDING   199   199        Heme 2 (covalent) (By similarity). 
BINDING   202   202        Heme 2 (covalent) (By similarity). 
BINDING   264   264        Heme 3 (covalent) (By similarity). 
BINDING   267   267        Heme 3 (covalent) (By similarity). 
BINDING   271   271        Substrate (By similarity). 
BINDING   319   319        Substrate (By similarity). 
BINDING   337   337        Heme 4 (covalent) (By similarity). 
BINDING   340   340        Heme 4 (covalent) (By similarity). 
BINDING   369   369        Heme 5 (covalent) (By similarity). 
BINDING   372   372        Heme 5 (covalent) (By similarity). 
Sequence information
Length: 538 AA [This is the length of the unprocessed precursor] Molecular weight: 60400 Da [This is the MW of the unprocessed precursor] CRC64: 48E64B46F2FB9CBB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIYLRFVWI LIIILNFLLN LFITTNGVII VNAFKKSLIV AASFASLSLF NSATAELVYK 

        70         80         90        100        110        120 
PLEQPVEPAK PDLKIESVNE KFAEKYPNQY NSWRSTANGD GENIIYADEE NPRLIVLWGG 

       130        140        150        160        170        180 
YAFAKEYNAP RGHFYAVTDV RNILRTGAPK TANDGPQAMA CWTCKGPDVP RLIAEWGEKD 

       190        200        210        220        230        240 
YFNAKWAKGG PEIVNSIGCA DCHDTTSKDF AEGKPALRIA RPHVLRALDA LEKATAEKDK 

       250        260        270        280        290        300 
AEGRPHNNLS FNTAARTEKR AEICANCHVE YYFAGDIKQV TFPWDNGQTV DDIEKYYDDI 

       310        320        330        340        350        360 
GFTDWTHSLS KAPMLKAQHP DFEIWSLGMH GKNGVTCVDC HMPKVQGADG KVYTDHQIQN 

       370        380        390        400        410        420 
PFEAFDSTCA NCHDQSKEKL RDIVTSRKKE VKDVMGRLED QVVKAHFEAK EAWDAGATKK 

       430        440        450        460        470        480 
EMEAALMDIR HAQWRWDYTA ASHGGHMHAP EVVLRVLASG LDKVADARTK LAVILTKHGV 

       490        500        510        520        530 
KTPVQIPDIS TADKAWKVMG IDIEKERKAK EEFLKTVVPQ WEQQAREKGL LVDPPAQK
P45017 in FASTA format

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