NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 17899 / DSM 180 / D;
PubMed=1396692 [NCBI, ExPASy, EBI, Israel, Japan]
Liebergesell M., Steinbuechel A.;
"Cloning and nucleotide sequences of genes relevant for biosynthesis of poly(3-hydroxybutyric acid) in Chromatium vinosum strain D.";
Eur. J. Biochem. 209:135-150(1992).

Comments

CATALYTIC ACTIVITY: (R)-3-hydroxyacyl-CoA + NADP⁺ = 3-oxoacyl-CoA + NADPH.
PATHWAY: Biopolymer metabolism; poly-(R)-3-hydroxybutyric acid biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L01112; AAA23325.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S29279; S29279.

3D structure databases

HSSP

Q9ZFY9; 1FK8. [HSSP ENTRY / PDB]

ModBase

P45375.

Family and domain databases

InterPro

IPR011283; Acetoacetyl-CoA_reductase.
IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

TIGRFAMs

TIGR01829; AcAcCoA_reduct; 1.

PROSITE

PS00061; ADH_SHORT; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NADP; Oxidoreductase; PHB biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 246`	`246`	`Acetoacetyl-CoA reductase.`	`PRO_0000054749`
`NP_BIND`	`7 31`	`25`	`NADP (By similarity).`
`ACT_SITE`	`153 153`		`Proton acceptor (By similarity).`
`BINDING`	`140 140`		`Substrate (By similarity).`

Sequence information

Length: 246 AA [This is the length of the unprocessed precursor]

Molecular weight: 26123 Da [This is the MW of the unprocessed precursor]

CRC64: 291E37450A1F54E9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MARIALVTGG IGGIGTSICT RLAKDGCTVV ANCHPSEAAA AEEWKQARAA EGFDIAVFTA 

        70         80         90        100        110        120 
DVSSFDDSAR MVREITEQVG PIDILVNCAG ITRDKTFKKM EQAHWEAVIN VNLNSVFNVT 

       130        140        150        160        170        180 
RQVWDGMLER GFGRIINISS VNGQRGQFGQ ANYSAAKAGM HGFTMALAQE GASKGVTVNT 

       190        200        210        220        230        240 
ISPGYVETAM TLAMNDDVRN SIISGIPMRR MAQPNEIAAA IAFLAGDESG YMTGANLPVN 


GGLFMH

P45375 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools