[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0378-1119(94)00910-K; PubMed=7535281 [NCBI, ExPASy, EBI, Israel, Japan] Rouhbakhsh D., Baumann P.; "Characterization of a putative 23S-5S rRNA operon of Buchnera aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding gene."; Gene 155:107-112(1995).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1126/science.1071278; PubMed=12089438 [NCBI, ExPASy, EBI, Israel, Japan] Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.; "50 million years of genomic stasis in endosymbiotic bacteria."; Science 296:2376-2379(2002).

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U09230; AAD09433.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE013218; AAM68017.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_660806.1; -.

3D structure databases

HSSP

P15770; 1NYT. [HSSP ENTRY / PDB]

ModBase

P46240.

Enzyme and pathway databases

BioCyc

BAPH198804:BUSG474-MON; -.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

P46240.

Genome annotation databases

GeneID

1005693; -.

GenomeReviews

AE013218_GR; BUsg_474.

KEGG

bas:BUsg474; -.

Phylogenomic databases

HOGENOM

P46240; -.

Genome annotation databases

CMR

P46240; BUsg_474.

Other

ProtoNet

P46240.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 273`	`273`	`Shikimate dehydrogenase.`	`PRO_0000135996`
`NP_BIND`	`131 135`	`5`	`NADP (By similarity).`
`CONFLICT`	`203 204`		`LP -> T (in Ref. 1).`
`CONFLICT`	`206 206`		`S -> I (in Ref. 1).`
`CONFLICT`	`212 212`		`T -> R (in Ref. 1; AAD09433).`

Sequence information

Length: 273 AA [This is the length of the unprocessed precursor]

Molecular weight: 30885 Da [This is the MW of the unprocessed precursor]

CRC64: 50507AF854774AF6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCKLEKFNYA LFGNPIDHSQ SPKIHNFFAT QTGILHIYKA INIPLDQFSS VVSDFFKKNI 

        70         80         90        100        110        120 
KGANVTAPFK KEAYFFSDKL TERAKIAQSV NTLKKISDKC ILGDNTDGIG LLSDLVRLNF 

       130        140        150        160        170        180 
IKKNFSILIL GAGGAVKGVL LPLLSLGCSV YILNRTILNA KILVKQFNKY GKIFVFDRQN 

       190        200        210        220        230        240 
FKQQNFDLVI NAMSRNTEKK NFLPLSLITS KTFFYDMNYS TRNTPFINWC SKAGGSFISN 

       250        260        270 
GIGMLVFQAA YSFLEWHNVL PEINYIINIL NIK

P46240 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools