ID   AROE_BUCAP              Reviewed;         273 AA.
AC   P46240;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   25-NOV-2008, entry version 61.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BUsg_474;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95212914; PubMed=7535281; DOI=10.1016/0378-1119(94)00910-K;
RA   Rouhbakhsh D., Baumann P.;
RT   "Characterization of a putative 23S-5S rRNA operon of Buchnera
RT   aphidicola (endosymbiont of aphids) unlinked to the 16S rRNA-encoding
RT   gene.";
RL   Gene 155:107-112(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; U09230; AAD09433.1; -; Genomic_DNA.
DR   EMBL; AE013218; AAM68017.1; -; Genomic_DNA.
DR   RefSeq; NP_660806.1; -.
DR   HSSP; P15770; 1NYT.
DR   GeneID; 1005693; -.
DR   GenomeReviews; AE013218_GR; BUsg_474.
DR   KEGG; bas:BUsg474; -.
DR   HOGENOM; P46240; -.
DR   BioCyc; BAPH198804:BUSG474-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR011342; Quinate/shikimate_5-DHase.
DR   InterPro; IPR013708; Shikimate_DHase-bd_N.
DR   InterPro; IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    273       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135996.
FT   NP_BIND     131    135       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
FT   CONFLICT    203    204       LP -> T (in Ref. 1).
FT   CONFLICT    206    206       S -> I (in Ref. 1).
FT   CONFLICT    212    212       T -> R (in Ref. 1; AAD09433).
SQ   SEQUENCE   273 AA;  30885 MW;  50507AF854774AF6 CRC64;
     MCKLEKFNYA LFGNPIDHSQ SPKIHNFFAT QTGILHIYKA INIPLDQFSS VVSDFFKKNI
     KGANVTAPFK KEAYFFSDKL TERAKIAQSV NTLKKISDKC ILGDNTDGIG LLSDLVRLNF
     IKKNFSILIL GAGGAVKGVL LPLLSLGCSV YILNRTILNA KILVKQFNKY GKIFVFDRQN
     FKQQNFDLVI NAMSRNTEKK NFLPLSLITS KTFFYDMNYS TRNTPFINWC SKAGGSFISN
     GIGMLVFQAA YSFLEWHNVL PEINYIINIL NIK
//