ID   DAPB2_MYCBO             Reviewed;         271 AA.
AC   P46829;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-NOV-2008, entry version 54.
DE   RecName: Full=Dihydrodipicolinate reductase;
DE            Short=DHPR;
DE            EC=1.3.1.26;
GN   Name=dapB;
OS   Mycobacterium bovis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Pasteur;
RX   MEDLINE=94292473; PubMed=8021227;
RA   Cirillo J.D., Weisbrod T.R., Banerjee A., Bloom B.R., Jacobs W.R. Jr.;
RT   "Genetic determination of the meso-diaminopimelate biosynthetic
RT   pathway of mycobacteria.";
RL   J. Bacteriol. 176:4424-4429(1994).
CC   -!- CATALYTIC ACTIVITY: 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) =
CC       2,3-dihydrodipicolinate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the dihydrodipicolinate reductase family.
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DR   EMBL; L24366; AAA21562.1; -; Genomic_DNA.
DR   PIR; A55517; A55517.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0008839; F:dihydrodipicolinate reductase activity; IEA:HAMAP.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00102; -; 1.
DR   InterPro; IPR000846; DapB.
DR   InterPro; IPR011770; DapB_bac/pln.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR20836; DapB_bac/pln; 1.
DR   Pfam; PF05173; DapB_C; 1.
DR   Pfam; PF01113; DapB_N; 1.
DR   ProDom; PD004105; DapB; 1.
DR   TIGRFAMs; TIGR00036; dapB; 1.
DR   PROSITE; PS01298; DAPB; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Cytoplasm; Diaminopimelate biosynthesis;
KW   Lysine biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    271       Dihydrodipicolinate reductase.
FT                                /FTId=PRO_0000141457.
SQ   SEQUENCE   271 AA;  27679 MW;  16DE4B090E481F6F CRC64;
     MTTRVALVGG TGKLGAIIAG VIDELDDFET VAVLGSDERS REIDAADLVV DASTPGVSID
     VVRAAIERGK NVLVGTSGWS TERIALVRPL VEAAGTGAVF IPNFSLGSVV ATALAAAAAP
     LFPSIEIVET HRETKVDSPS GTAVRTAELI ADARVGVGPV ESPHVDQRAR GQQVASVPIH
     SLRRPGVIAN EETILSGPGE SLTIVHDTIE PARAYAPGIR IALAARADAR GVTIGLDALI
     DLGLAPRPAA PVIEVVDEGS VPGQVARVTG A
//