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UniProtKB/Swiss-Prot entry P47199

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name QOR_MOUSE
Primary accession number P47199
Secondary accession numbers Q62508 Q99L63
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 70)
Name and origin of the protein
Protein name Quinone oxidoreductase
Synonyms EC 1.6.5.5
NADPH:quinone reductase
Zeta-crystallin
Gene name
Name: Cryz
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8170370 [NCBI, ExPASy, EBI, Israel, Japan]
Gonzalez P., Hernandez-Calzadilla C., Rao P.V., Rodriguez I.R., Zigler J.S. Jr., Borras T.;
"Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse.";
Mol. Biol. Evol. 11:305-315(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 NUCLEOTIDE SEQUENCE [MRNA] OF 130-331.
STRAIN=C57BL/6J;
TISSUE=Brain cortex;
DOI=10.1006/bbrc.1996.0313; PubMed=8645260 [NCBI, ExPASy, EBI, Israel, Japan]
Kajiwara K., Nagawawa H., Shimizu-Nishikawa K., Ookura T., Kimura M., Sugaya E.;
"Molecular characterization of seizure-related genes isolated by differential screening.";
Biochem. Biophys. Res. Commun. 219:795-799(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S70056; AAB30620.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003800; AAH03800.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D78646; BAA11463.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A54932; A54932.
RefSeq NP_034098.1; -.
UniGene Mm.374855
3D structure databases
HSSP P39462; 1JVB. [HSSP ENTRY / PDB]
SMR P47199; 6-331.
ModBase P47199.
PTM databases
PhosphoSite P47199; -.
2D gel databases
REPRODUCTION-2DPAGE P47199; -.
Organism-specific databases
MGI MGI:88527; Cryz.
Gene expression databases
ArrayExpress P47199; -.
CleanEx MM_CRYZ; -.
GermOnline ENSMUSG00000028199; Mus musculus.
Ontologies
GO
GO:0003960; Molecular function: NADPH:quinone reductase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002364; Quin_OxRdtase/zeta-crystal_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS01162; QOR_ZETA_CRYSTAL; 1.
BLOCKS P47199.
Genome annotation databases
Ensembl ENSMUSG00000028199; Mus musculus. [Contig view]
GeneID 12972; -.
KEGG mmu:12972; -.
Phylogenomic databases
HOGENOM P47199; -.
HOVERGEN P47199; -.
Other
SOURCE Cryz; Mus musculus.
ProtoNet P47199.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   331  331     Quinone oxidoreductase. PRO_0000160908
CONFLICT   58    58        A -> T (in Ref. 2; AAH03800). 
CONFLICT   131   133        IPY -> TMD (in Ref. 3). 
Sequence information
Length: 331 AA [This is the length of the unprocessed precursor] Molecular weight: 35269 Da [This is the MW of the unprocessed precursor] CRC64: 35816C043EFE16A2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATGQKLMRA IRVFEFGGPE VLKLQSDVVV PVPQSHQVLI KVHACGVNPV ETYIRSGAYS 

        70         80         90        100        110        120 
RKPALPYTPG SDVAGIIESV GDKVSAFKKG DRVFCYSTVS GGYAEFALAA DDTIYPLPET 

       130        140        150        160        170        180 
LNFRQGAALG IPYFTACRAL FHSARARAGE SVLVHGASGG VGLATCQIAR AHGLKVLGTA 

       190        200        210        220        230        240 
GSEEGKKLVL QNGAHEVFNH KEANYIDKIK MSVGDKDKGV DVIIEMLANE NLSNDLKLLS 

       250        260        270        280        290        300 
HGGRVVVVGC RGPIEINPRD TMAKETSIIG VSLSSSTKEE FQQFAGLLQA GIEKGWVKPV 

       310        320        330 
IGSEYPLEKA AQAHEDIIHG SGKTGKMILL L
P47199 in FASTA format

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