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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C3H;
PubMed=8148869 [NCBI, ExPASy, EBI, Israel, Japan]
Vasiliou V.,
Reuter S.F.,
Kozak C.A.,
Nebert D.W.;
"Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels.";
Pharmacogenetics 3:281-290(1993).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
Vasiliou V.,
Reuter S.F.,
Nebert D.W.;
"Organization and characterization of the murine cytosolic TCDD-inducible aldehyde dehydrogenase gene (ahd4).";
Toxicologist 14:410-410(1994).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANTS ALD3A1C ARG-88; ASN-154; ARG-305 AND VAL-352.
STRAIN=DBA/2, and SWR/J;
PubMed=10376761 [NCBI, ExPASy, EBI, Israel, Japan]
Shiao T.,
Tran P.,
Siegel D.,
Lee J.,
Vasiliou V.;
"Four amino acid changes are associated with the Aldh3a1 locus polymorphism in mice which may be responsible for corneal sensitivity to ultraviolet light.";
Pharmacogenetics 9:145-153(1999).
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[4]
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FUNCTION.
STRAIN=CD-1;
PubMed=11784860 [NCBI, ExPASy, EBI, Israel, Japan]
Nees D.W.,
Wawrousek E.F.,
Robison W.G. Jr.,
Piatigorsky J.;
"Structurally normal corneas in aldehyde dehydrogenase 3a1-deficient mice.";
Mol. Cell. Biol. 22:849-855(2002).
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- FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes and in preventing corneal damage caused by ultraviolet light.
- CATALYTIC ACTIVITY: An aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H.
- SUBUNIT: Homodimer (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Constitutively expressed in cornea, stomach, skin, bladder and lungs. Lowest expression levels in lungs and bladder.
- POLYMORPHISM: There are two alleles, Ald3a1a and Ald3a1c. Ald3a1c codes for a low activity enzyme and is associated with extensive corneal clouding after exposure to ultraviolet light. Ald3a1a encodes the high activity enzyme.
- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 453 AA [This is the length of the unprocessed precursor] |
Molecular weight: 50467 Da [This is the MW of the unprocessed precursor] |
CRC64: 9D94FE30094AD76A [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSNISSIVNR ARDAFNSGKT RPLQFRVEQL EALQRMINEN LKGISKALAS NLRKNEWTSY
70 80 90 100 110 120
YEEVAHVLDE IDFTIKGLSD WAEDEPVGKT RQTQEDDLYI HSEPLGVVLV IGAWNYPFNL
130 140 150 160 170 180
TIQPMVGAIA AGNAVVLKPS EVSDHMADLL STLIPQYMDK DLYPVIKGGV PETTELLKEK
190 200 210 220 230 240
FDHIMYTGST AVGKIVMAAA AKHLTPVTLE LGGKSPCYVD KDCDLDVACR RIAWGKFMNS
250 260 270 280 290 300
GQTCVAPDYI LCDPSIQNEI VEKLKKSLKD FYGEDAKQSH DYGRIINDRH FQRVINLIDS
310 320 330 340 350 360
KKVAHGGTWD QPSRYIAPTI LVDVDPQSPV MQEEIFGPVM PIVCVRSLDE AIKFINQREK
370 380 390 400 410 420
PLALYVFSNN DKVIKKMIAE TSSGGVTAND VIVHITVPTL PFGGVGNSGM GAYHGKKSFE
430 440 450
TFSHRRSCLV RSLRNEEANK ARYPPSPAKM PRH
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P47739 in FASTA format |
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