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UniProtKB/Swiss-Prot entry P48020

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH1_SOLTU
Primary accession number P48020
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 57)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Synonyms HMG-CoA reductase 1
HMGR1
HMGR
EC 1.1.1.34
Gene name
Name: HMG1
From
Solanum tuberosum (Potato) [TaxID: 4113] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Kennebec;
TISSUE=Tuber;
DOI=10.1105/tpc.4.10.1333; PubMed=1283354 [NCBI, ExPASy, EBI, Israel, Japan]
Choi D., Ward B.L., Bostock R.M.;
"Differential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in response to Phytophthora infestans and to its elicitor arachidonic acid.";
Plant Cell 4:1333-1344(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L01400; AAA93498.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S59944; S59944.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase P48020.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; FALSE_NEG.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P48020.
Other
ProtoNet P48020.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   596  596     3-hydroxy-3-methylglutaryl-coenzyme A reductase 1. PRO_0000114448
TRANSMEM   41    61  21     Potential. 
TRANSMEM   83   103  21     Potential. 
REGION   104   183  80     Linker (By similarity). 
REGION   184   596  413     Catalytic (By similarity). 
ACT_SITE   278   278        Charge relay system (By similarity). 
ACT_SITE   410   410        Charge relay system (By similarity). 
ACT_SITE   486   486        Charge relay system (By similarity). 
ACT_SITE   584   584        Proton donor (By similarity). 
CARBOHYD   342   342        N-linked (GlcNAc...) (Potential). 
CARBOHYD   455   455        N-linked (GlcNAc...) (Potential). 
CARBOHYD   588   588        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 596 AA [This is the length of the unprocessed precursor] Molecular weight: 63917 Da [This is the MW of the unprocessed precursor] CRC64: 4E7060D3ADC6EE60 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDVRRRPVKP LYTSKDASAG EPLKQQEVSS PKASDALPLP LYLTNGLFFT MFFSVMYFLL 

        70         80         90        100        110        120 
VRWREKIRNS IPLHVVTLSE LLAMVSLIAS VIYLLGFFGI GFVQSFVSRS NSDSWDIEDE 

       130        140        150        160        170        180 
NAEQLIIEED SRRGPCAAAT TLGCVVPPPP VRKIAPMVPQ QPAKVALSQT EKPSPIIMPA 

       190        200        210        220        230        240 
LSEDDEEIIQ SVVQGKTPSY SLESKLGDCM RAASIRKEAL QRITGKSLEG LPLEGFDYSS 

       250        260        270        280        290        300 
ILGQCCEMPV GYVQIPVGIA GPLLLDGREY SVPMATTEGC LVASTNRGCK AIFVSGGADS 

       310        320        330        340        350        360 
VLLRDGMTRA PVVRFTTAKR AAELKFFVED PLNFETLSLM FNKSSRFARL QGIQCAIAGK 

       370        380        390        400        410        420 
NLYITFSCST GDAMGMNMVS KGVQNVLDYL QSEYPDMDVI GISGNFCSDK KPAAVNWIEG 

       430        440        450        460        470        480 
RGKSVVCEAI IKEEVVKKVL KTEVAALVEL NMLKNLTGSA MAGALGGFNA HASNIVSAVY 

       490        500        510        520        530        540 
LATGQDPAQN VESSHCITMM EAVNDGKDLH VSVTMPSIEV GTVGGGTQLA SQSACLNLLG 

       550        560        570        580        590 
VKGANRDAPG SNARLLATIV AGSVLAGELS LMSAISAGQL VKSHMKYNRS IKDISK
P48020 in FASTA format

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View entry in raw text format (no links)
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