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UniProtKB/Swiss-Prot entry P49250

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AMO_KLEAE
Primary accession number P49250
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 53)
Name and origin of the protein
Protein name Primary amine oxidase [Precursor]
Synonyms EC 1.4.3.21
Copper amine oxidase
Monamine oxidase
Tyramine oxidase
Gene name
Name: maoA
Synonyms: tynA
From
Klebsiella aerogenes [TaxID: 28451] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Klebsiella.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 31-41.
STRAIN=W70;
PubMed=1556068 [NCBI, ExPASy, EBI, Israel, Japan]
Sugino H., Sasaki M., Azakami H., Yamashita M., Murooka Y.;
"A monoamine-regulated Klebsiella aerogenes operon containing the monoamine oxidase structural gene (maoA) and the maoC gene.";
J. Bacteriol. 174:2485-2492(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D10208; BAA01060.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P46883; 1OAC. [HSSP ENTRY / PDB]
SMR P49250; 35-754.
ModBase P49250.
Ontologies
GO
GO:0042597; Cellular component: periplasmic space (inferred from electronic annotation from UniProtKB-KW).
GO:0008131; Molecular function: amine oxidase activity (inferred from electronic annotation from InterPro).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from InterPro).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from InterPro).
GO:0006584; Biological process: catecholamine metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000269; Cu_amine_oxidase.
IPR012854; Cu_amine_oxidase-like_N.
IPR015798; Cu_amine_oxidase_C.
IPR015800; Cu_amine_oxidase_N2.
IPR015801; Cu_amine_oxidase_N2/3.
IPR015802; Cu_amine_oxidase_N3.
Graphical view of domain structure.
Gene3D G3DSA:3.30.457.10; Cu_amine_oxidase-like_N; 1.
G3DSA:3.10.450.40; CuNH_oxidase; 2.
G3DSA:2.70.98.20; Lyase_8_central; 1.
PANTHER PTHR10638; CuNH_oxidase; 1.
Pfam PF01179; Cu_amine_oxid; 1.
PF07833; Cu_amine_oxidN1; 1.
PF02727; Cu_amine_oxidN2; 1.
PF02728; Cu_amine_oxidN3; 1.
Pfam graphical view of domain structure.
PROSITE PS01164; COPPER_AMINE_OXID_1; 1.
PS01165; COPPER_AMINE_OXID_2; 1.
ProtoNet P49250.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Catecholamine metabolism; Copper; Direct protein sequencing; Metal-binding; Oxidoreductase; Periplasm; Signal; TPQ.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    30  30      
CHAIN   31   755  725     Primary amine oxidase. PRO_0000035674
ACT_SITE   413   413        Proton acceptor (By similarity). 
ACT_SITE   496   496        Schiff-base intermediate with substrate; via topaquinone (By similarity). 
METAL   554   554        Copper (Potential). 
METAL   556   556        Copper (Potential). 
METAL   719   719        Copper (Potential). 
MOD_RES   496   496        2',4',5'-topaquinone (By similarity). 
Sequence information
Length: 755 AA [This is the length of the unprocessed precursor] Molecular weight: 83577 Da [This is the MW of the unprocessed precursor] CRC64: 7B5552283CD93EFF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MANGLKFSPR KTALALAVAV VCAWQSPVFA HGSEAHMVPL DKTLQEFGAD VQWDDYAQMF 

        70         80         90        100        110        120 
TLIKDGAYVK VKPGAKTAIV NGKSLDLPVP VVMKEGKAWV SDTFINDVFQ SGLDQTFQVE 

       130        140        150        160        170        180 
KRPHPLNSLS AAEISKAVTI VKAAPEFQPN TRFTEISLHE PDKAAVWAFA LQGTPVDAPR 

       190        200        210        220        230        240 
TADVVMLDGK HVIEAVVDLQ NKKILSWTPI KGAHGMVLLD DFVSVQNIIN TSSEFAEVLK 

       250        260        270        280        290        300 
KHGITDPGKV VTTPLTVGFF DGKDGLQQDA RLLKVVSYLD TGDGNYWAHP IENLVAVVDL 

       310        320        330        340        350        360 
EAKKIIKIEE GPVIPVPMEP RPYDGRDRNA PAVKPLEITE PEGKNYTITG DTIHWQNWDF 

       370        380        390        400        410        420 
HLRLNSRVGP ILSTVTYNDN GTKRQVMYEG SLGGMIVPYG DPDVGWYFKA YLDSGDYGMG 

       430        440        450        460        470        480 
TLTSPIVRGK DAPSNAVLLD ETIADYTGKP TTIPGAVAIF ERYAGPEYKH LEMGKPNVST 

       490        500        510        520        530        540 
ERRELVVRWI STVGNYDYIF DWVFHDNGTI GIDAGATGIE AVKGVLAKTM HDPSAKEDTR 

       550        560        570        580        590        600 
YGTLIDHNIV GTTHQHIYNF RLDLDVDGEN NTLVAMDPEV KPNTAGGPRT STMQVNQYTI 

       610        620        630        640        650        660 
DSEQKAAQKF DPGTIRLLSN TSKENRMGNP VSYQIIPYAG GTHPAATGAK FAPDEWIYHR 

       670        680        690        700        710        720 
LSFMDKQLWV TRYHPTERYP EGKYPNRSAH DTGLGQYAKD DESLTNHDDV VWITTGTTHV 

       730        740        750 
ARAEEWPIMP TEWALALLKP WNFFDETPTL GEKKK
P49250 in FASTA format

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