[1]	PROTEIN SEQUENCE. TISSUE=Heart; PubMed=9504812 [NCBI, ExPASy, EBI, Israel, Japan] Dunn M.J., Corbett J.M., Wheeler C.H.; "HSC-2DPAGE and the two-dimensional gel electrophoresis database of dog heart proteins."; Electrophoresis 18:2795-2802(1997).

Comments

FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate.
ENZYME REGULATION: E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit (By similarity).
SUBUNIT: Tetramer of 2 alpha and 2 beta subunits.
SUBCELLULAR LOCATION: Mitochondrion matrix.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

2D gel databases

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
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Family and domain databases

Phylogenomic databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycolysis; Mitochondrion; Oxidoreductase; Phosphoprotein; Pyruvate; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >13`	`>13`	`Pyruvate dehydrogenase E1 component subunit alpha, somatic form.`	`PRO_0000162214`
`NON_TER`	`13 13`

Sequence information

Length: 13 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 1513 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: C97EEBF844085B19 [This is a checksum on the sequence]

        10 
XXDATFEIKK XDL

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools