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UniProtKB/Swiss-Prot entry P51647

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1A1_RAT
Primary accession number P51647
Secondary accession number O09184
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 67)
Name and origin of the protein
Protein name Retinal dehydrogenase 1
Synonyms RALDH 1
RalDH1
EC 1.2.1.36
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
ALHDII
ALDH-E1
Gene name
Name: Aldh1a1
Synonyms: Aldh
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Kidney;
DOI=10.1016/0378-1119(96)81752-5; PubMed=8543180 [NCBI, ExPASy, EBI, Israel, Japan]
Bhat P.V., Labrecque J., Boutin J.-M., Lacroix A., Yoshida A.;
"Cloning of a cDNA encoding rat aldehyde dehydrogenase with high activity for retinal oxidation.";
Gene 166:303-306(1995).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
PubMed=9059608 [NCBI, ExPASy, EBI, Israel, Japan]
Kathmann E.C., Lipsky J.J.;
"A preliminary report on the cloning of a constitutively expressed rat liver cytosolic ALDH cDNA by PCR.";
Adv. Exp. Med. Biol. 414:69-72(1997).
[3]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1006/bbrc.1997.6998; PubMed=9240474 [NCBI, ExPASy, EBI, Israel, Japan]
Kathmann E.C., Lipsky J.J.;
"Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase.";
Biochem. Biophys. Res. Commun. 236:527-531(1997).
[4]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Napoli J.L., Penzes P., Wang X., Sperkova Z.;
"Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli.";
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
[5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
 PROTEIN SEQUENCE OF 2-19; 80-91; 96-121; 205-225; 237-258 AND 394-438.
STRAIN=Sprague-Dawley;
TISSUE=Kidney;
PubMed=7832787 [NCBI, ExPASy, EBI, Israel, Japan]
Labrecque J., Dumas F., Lacroix A., Bhat P.V.;
"A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.";
Biochem. J. 305:681-684(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L42009; AAA96657.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF001896; AAC53304.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF001898; AAC53306.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF001897; AAC53305.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U79118; AAB63423.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC061526; AAH61526.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC4524; JC4524.
JC5553; JC5553.
RefSeq NP_071852.2; -.
UniGene Rn.6132
3D structure databases
HSSP P51977; 1BXS. [HSSP ENTRY / PDB]
ModBase P51647.
Organism-specific databases
RGD 2087; Aldh1a1.
Gene expression databases
ArrayExpress P51647; -.
GermOnline ENSRNOG00000017619; Rattus norvegicus.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS P51647.
Genome annotation databases
Ensembl ENSRNOG00000017619; Rattus norvegicus. [Contig view]
GeneID 24188; -.
KEGG rno:24188; -.
Phylogenomic databases
HOVERGEN P51647; -.
Other
ProtoNet P51647.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   501  500     Retinal dehydrogenase 1. PRO_0000056419
NP_BIND   246   251  6     NAD (By similarity). 
ACT_SITE   269   269        Proton acceptor (By similarity). 
ACT_SITE   303   303        Nucleophile (By similarity). 
SITE   170   170  1     Transition state stabilizer (By similarity). 
MOD_RES   2     2        N-acetylserine (Probable). 
CONFLICT   100   100        R -> C (in Ref. 1; AAA96657). 
CONFLICT   106   106        I -> M (in Ref. 6; AA sequence). 
CONFLICT   170   170        N -> E (in Ref. 1; AAA96657). 
Sequence information
Length: 501 AA [This is the length of the unprocessed precursor] Molecular weight: 54459 Da [This is the MW of the unprocessed precursor] CRC64: A3614C21BCE7E144 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSPAQPAVP APLANLKIQH TKIFINNEWH DSVSGKKFPV LNPATEEVIC HVEEGDKADV 

        70         80         90        100        110        120 
DKAVKAARQA FQIGSPWRTM DASERGRLLN KLADLMERDR LLLATIEAIN GGKVFANAYL 

       130        140        150        160        170        180 
SDLGGSIKAL KYCAGWADKI HGQTIPSDGD IFTFTRREPI GVCGQIIPWN FPLLMFIWKI 

       190        200        210        220        230        240 
GPALSCGNTV VVKPAEQTPL TALHMASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDVD 

       250        260        270        280        290        300 
KVAFTGSTQV GKLIKEAAGK SNLKRVTLEL GGKSPCIVFA DADLDIAVEF AHHGVFYHQG 

       310        320        330        340        350        360 
QCCVAASRIF VEESVYDEFV RKSVERAKKY VLGNPLTQGI NQGPQIDKEQ HDKILDLIES 

       370        380        390        400        410        420 
GKKEGAKLEC GGGRWGNKGF FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSIDDVIKR 

       430        440        450        460        470        480 
ANNTTYGLAA GVFTKDLDRA ITVSSALQAG VVWVNCYMIL SAQCPFGGFK MSGNGRELGE 

       490        500 
HGLYEYTELK TVAMKISQKN S
P51647 in FASTA format

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