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UniProtKB/Swiss-Prot entry P54783

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALO_YEAST
Primary accession number P54783
Secondary accession number O42618
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name D-arabinono-1,4-lactone oxidase
Synonyms ALO
EC 1.1.3.37
L-galactono-gamma-lactone oxidase
Gene name
Name: ALO1
OrderedLocusNames: YML086C
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 86-105 AND 349-363.
STRAIN=ATCC 44774 / DBY747;
PubMed=10094636 [NCBI, ExPASy, EBI, Israel, Japan]
Huh W.-K., Lee B.-H., Kim S.-T., Kim Y.-R., Rhie G.-E., Baek Y.-W., Hwang C.-S., Lee J.-S., Kang S.-O.;
"D-erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.";
Mol. Microbiol. 30:895-903(1998).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Nishikimi M., Ohata Y., Ishikawa T.;
"Identification of the yeast genomic sequence encoding L-galactono-gamma-lactone oxidase.";
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169872 [NCBI, ExPASy, EBI, Israel, Japan]
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
Nature 387:90-93(1997).
[4]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[5]
 LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U40390; AAC98538.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB009401; BAA23804.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z46660; CAA86652.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY693120; AAT93139.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S49641; S49641.
RefSeq NP_013624.1; -.
3D structure databases
ModBase P54783.
Protein-protein interaction databases
IntAct P54783; -.
Organism-specific databases
CYGD YML086c; -.
SGD S000004551; ALO1.
Yeast-GFP YML086C.
Gene expression databases
GermOnline YML086C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0031307; Cellular component: integral to mitochondrial outer membrane (inferred from direct assay from SGD).
GO:0003885; Molecular function: D-arabinono-1,4-lactone oxidase activity (inferred from direct assay from SGD).
GO:0006979; Biological process: response to oxidative stress (inferred from mutant phenotype from SGD).
QuickGo view.
Family and domain databases
InterPro IPR007173; ALO.
IPR010031; FAD_lactone_oxidase.
IPR006094; Oxid_FAD_bind_N.
IPR006093; Oxy_OxRdtase_FAD_BS.
Graphical view of domain structure.
Pfam PF04030; ALO; 1.
PF01565; FAD_binding_4; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01678; FAD_lactone_ox; 1.
PROSITE PS51387; FAD_PCMH; 1.
PS00862; OX2_COVAL_FAD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P54783.
Proteomic databases
PeptideAtlas P54783; -.
Genome annotation databases
Ensembl YML086C; Saccharomyces cerevisiae. [Contig view]
GeneID 854888; -.
GenomeReviews Z71257_GR; YML086C.
KEGG sce:YML086C; -.
NMPDR fig|4932.3.peg.4661; -.
Phylogenomic databases
HOGENOM P54783; -.
Other
LinkHub P54783; -.
ProtoNet P54783.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mitochondrion; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   526  526     D-arabinono-1,4-lactone oxidase. PRO_0000128171
DOMAIN   19   193  175     FAD-binding PCMH-type. 
MOD_RES   56    56        Tele-8alpha-FAD histidine (By similarity). 
CONFLICT   417   417        A -> P (in Ref. 2; BAA23804). 
Sequence information
Length: 526 AA [This is the length of the unprocessed precursor] Molecular weight: 59494 Da [This is the MW of the unprocessed precursor] CRC64: 942177A74A738EC8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTIPFRKNY VFKNWAGIYS AKPERYFQPS SIDEVVELVK SARLAEKSLV TVGSGHSPSN 

        70         80         90        100        110        120 
MCVTDEWLVN LDRLDKVQKF VEYPELHYAD VTVDAGMRLY QLNEFLGAKG YSIQNLGSIS 

       130        140        150        160        170        180 
EQSVAGIIST GSHGSSPYHG LISSQYVNLT IVNGKGELKF LDAENDPEVF KAALLSVGKI 

       190        200        210        220        230        240 
GIIVSATIRV VPGFNIKSTQ EVITFENLLK QWDTLWTSSE FIRVWWYPYT RKCVLWRGNK 

       250        260        270        280        290        300 
TTDAQNGPAK SWWGTKLGRF FYETLLWIST KIYAPLTPFV EKFVFNRQYG KLEKSSTGDV 

       310        320        330        340        350        360 
NVTDSISGFN MDCLFSQFVD EWGCPMDNGL EVLRSLDHSI AQAAINKEFY VHVPMEVRCS 

       370        380        390        400        410        420 
NTTLPSEPLD TSKRTNTSPG PVYGNVCRPF LDNTPSHCRF APLENVTNSQ LTLYINATIY 

       430        440        450        460        470        480 
RPFGCNTPIH KWFTLFENTM MVAGGKPHWA KNFLGSTTLA AGPVKKDTDY DDFEMRGMAL 

       490        500        510        520 
KVEEWYGEDL KKFRKIRKEQ DPDNVFLANK QWAIINGIID PSELSD
P54783 in FASTA format

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