NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/bbrc.1994.1244; PubMed=8123043 [NCBI, ExPASy, EBI, Israel, Japan]
Hoshino T., Kosuge T., Hidaka Y., Tabata K., Nakahara T.;
"Molecular cloning and sequence analysis of the proC gene encoding delta 1-pyrroline-5-carboxylate reductase from an extremely thermophilic eubacterium Thermus thermophilus.";
Biochem. Biophys. Res. Commun. 199:410-417(1994).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt956; PubMed=15064768 [NCBI, ExPASy, EBI, Israel, Japan]
Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
"The genome sequence of the extreme thermophile Thermus thermophilus.";
Nat. Biotechnol. 22:547-553(2004).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

D25413; BAA05001.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017221; AAS80848.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_004475.1; -.

3D structure databases

ModBase

P54893.

Enzyme and pathway databases

BioCyc

TTHE262724:TT_C0500-MON; -.

Family and domain databases

InterPro

IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

GeneID

2775949; -.

GenomeReviews

AE017221_GR; TT_C0500.

Phylogenomic databases

HOGENOM

P54893; -.

Other

LinkHub

P54893; -.

Genome annotation databases

CMR

P54893; TT_C0500.

Other

ProtoNet

P54893.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 261`	`261`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187309`

Sequence information

Length: 261 AA [This is the length of the unprocessed precursor]

Molecular weight: 27819 Da [This is the MW of the unprocessed precursor]

CRC64: 3435C3A8F4299B3E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRLAFVGLGK MGRSILKGAL ERGFLRPEEV GVLGRTPERS RELAEPFGVR PLTRADLGMA 

        70         80         90        100        110        120 
ERVLIAVQPR DFPALAPEIA HHRLGYISIM AGISTSVLAR RLDNRRVVRA MPNLAVVIGE 

       130        140        150        160        170        180 
SSTALTALKE AREAEDLAFA RALFATVGDV YEIPEHLFDA FTGMSASAPA YLAVVAEALA 

       190        200        210        220        230        240 
DAGVKMGMPR ALALRLAADA LAATGELLKG RHPAQVKDEV ASPGGTTIHG LHALEARAVR 

       250        260 
AAFYEAVEAA TRRGHELGES E

P54893 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools