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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Trophoblast;
DOI=10.1038/330377a0; PubMed=2446135 [NCBI, ExPASy, EBI, Israel, Japan]
Imakawa K.,
Antony R.V.,
Kazemi M.,
Marotti K.R.,
Polites H.G.,
Roberts R.M.;
"Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm.";
Nature 330:377-379(1987).
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[2]
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FUNCTION.
DOI=10.1210/en.137.3.1144; PubMed=8603586 [NCBI, ExPASy, EBI, Israel, Japan]
Spencer T.E.,
Bazer F.W.;
"Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium.";
Endocrinology 137:1144-1147(1996).
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[3]
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CIRCULAR DICHROISM ANALYSIS, AND 3D-STRUCTURE MODELING.
DOI=10.1093/protein/7.7.863; PubMed=7971949 [NCBI, ExPASy, EBI, Israel, Japan]
Jarpe M.A.,
Johnson H.M.,
Bazer F.W.,
Ott T.L.,
Curto E.V.,
Krishna N.R.,
Pontzer C.H.;
"Predicted structural motif of IFN tau.";
Protein Eng. 7:863-867(1994).
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[4]
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3D-STRUCTURE MODELING.
PubMed=8746786 [NCBI, ExPASy, EBI, Israel, Japan]
Senda T.,
Saitoh S.,
Mitsui Y.,
Li J.,
Roberts R.M.;
"A three-dimensional model of interferon-tau.";
J. Interferon Cytokine Res. 15:1053-1060(1995).
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[5]
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REVIEW.
DOI=10.1016/S0300-9084(99)80029-7; PubMed=9865498 [NCBI, ExPASy, EBI, Israel, Japan]
Martal J.L.,
Chene N.M.,
Huynh L.P.,
L'Haridon R.M.,
Reinaud P.B.,
Guillomot M.W.,
Charlier M.A.,
Charpigny S.Y.;
"IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities.";
Biochimie 80:755-777(1998).
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[6]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 24-195, AND DISULFIDE BONDS.
DOI=10.1006/jmbi.1998.2480; PubMed=9931256 [NCBI, ExPASy, EBI, Israel, Japan]
Radhakrishnan R.,
Walter L.J.,
Subramaniam P.S.,
Johnson H.M.,
Walter M.R.;
"Crystal structure of ovine interferon-tau at 2.1 A resolution.";
J. Mol. Biol. 286:151-162(1999).
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- FUNCTION: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
- SUBCELLULAR LOCATION: Secreted. Note=Secreted into the uterine lumen.
- TISSUE SPECIFICITY: Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.
- DEVELOPMENTAL STAGE: Major secretory product synthesized by the sheep conceptus between days 13 and 21 of pregnancy.
- MISCELLANEOUS: IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They encode for proteins very similar in sequence but with different biological potency and pattern of expression.
- SIMILARITY: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 195 AA [This is the length of the unprocessed precursor] |
Molecular weight: 22193 Da [This is the MW of the unprocessed precursor] |
CRC64: A4965AE25DEA5BC9 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAFVLSLLMA LVLVSYGPGG SLGCYLSRKL MLDARENLKL LDRMNRLSPH SCLQDRKDFG
70 80 90 100 110 120
LPQEMVEGDQ LQKDQAFPVL YEMLQQSFNL FYTEHSSAAW DTTLLEQLCT GLQQQLDHLD
130 140 150 160 170 180
TCRGQVMGEE DSELGNMDPI VTVKKYFQGI YDYLQEKGYS DCAWEIVRVE MMRALTVSTT
190
LQKRLTKMGG DLNSP
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P56828 in FASTA format |
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