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UniProtKB/Swiss-Prot entry P56961

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARODE_CHLMU
Primary accession number P56961
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 56)
Name and origin of the protein
Protein name Shikimate biosynthesis protein aroDE
Synonyms None
Includes 3-dehydroquinate dehydratase
     (3-dehydroquinase)
     (EC 4.2.1.10)
     (Type I DHQase)
Shikimate dehydrogenase
     (EC 1.1.1.25)
Gene name
Name: aroE
Synonyms: aroD/E
OrderedLocusNames: TC_0649
From
Chlamydia muridarum [TaxID: 83560] [HAMAP proteome]
Taxonomy Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MoPn / Nigg;
DOI=10.1093/nar/28.6.1397; PubMed=10684935 [NCBI, ExPASy, EBI, Israel, Japan]
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.";
Nucleic Acids Res. 28:1397-1406(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE002160; AAF39475.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G81679; G81679.
RefSeq NP_297023.1; -.
3D structure databases
ModBase P56961.
Enzyme and pathway databases
BioCyc CMUR243161:TC_0649-MON; -.
Ontologies
GO
GO:0003855; Molecular function: 3-dehydroquinate dehydratase activity (inferred from electronic annotation from HAMAP).
GO:0004764; Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073; Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00214; fused; 1.
MF_00222; fused; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR001381; DHquinase_I.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01487; DHquinase_I; 1.
PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.
ProDom PD005337; DHquinase_I; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00507; aroE; 1.
PROSITE PS01028; DEHYDROQUINASE_I; FALSE_NEG.
BLOCKS P56961.
Genome annotation databases
GeneID 1246010; -.
GenomeReviews AE002160_GR; TC_0649.
KEGG cmu:TC0649; -.
TIGR TC_0649; -.
Phylogenomic databases
HOGENOM P56961; -.
Other
ProtoNet P56961.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Lyase; Multifunctional enzyme; NADP; Oxidoreductase; Schiff base.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   478  478     Shikimate biosynthesis protein aroDE. PRO_0000138822
NP_BIND   337   341  5     NADP (By similarity). 
REGION   1   208  208     3-dehydroquinate dehydratase. 
REGION   209   478  270     Shikimate 5-dehydrogenase. 
ACT_SITE   110   110        Proton acceptor (By similarity). 
ACT_SITE   133   133        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 478 AA [This is the length of the unprocessed precursor] Molecular weight: 53211 Da [This is the MW of the unprocessed precursor] CRC64: 199EEF5251205AB9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLCTIIRGPS FLEARNQLLR SLKKCRCFEM RADLLTVSDA ELQKLILLAP ISVLTWKKPP 

        70         80         90        100        110        120 
SCTPQAWVKK IQSLAKLHPT YLDLDKDFPE EEILHIRHLH PNIKIIRSLH TSEHTDITQL 

       130        140        150        160        170        180 
YTQMLASSID YYKLAVSPAS TTDLLNICRQ KHSLPQNTTV LCLGKIGQSS RILSPILQNP 

       190        200        210        220        230        240 
FTYTIPTGAD PVAPGQLSLN HHYFYNFTNL SPQSQICALI GDTSRSIGHL THNPFFSQLS 

       250        260        270        280        290        300 
IPCPYVKLPL TPQELPEFFS SIRALPFLGI SVTSPLKTAI IPFLDKQDSS VKLSGSCNTL 

       310        320        330        340        350        360 
VIRQGEIIGY DTDGEGLFSV LTQHNMDLSN QRVAILGAGG AARSIAARLS RTGCELLIFN 

       370        380        390        400        410        420 
RTKIHAEAIA SRYQAQAFDI KDLPLHSVSL IINCLPPSSI IPQALAPLIV DINTLPKHNS 

       430        440        450        460        470 
FTQYARLKGC SIIYGHEMFA QQALLQFRLW FPTHSFNHLE KNFSRRAAVL ASLFSIAA
P56961 in FASTA format

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