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UniProtKB/Swiss-Prot entry P57300

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_BUCAI
Primary accession number P57300
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on December 1, 2000 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 50)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: BU204
From
Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) [TaxID: 118099] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tokyo 1998;
DOI=10.1038/35024074; PubMed=10993077 [NCBI, ExPASy, EBI, Israel, Japan]
Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
"Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.";
Nature 407:81-86(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000003; BAB12921.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_240035.1; -.
3D structure databases
HSSP P49058; 1EEP. [HSSP ENTRY / PDB]
ModBase P57300.
Enzyme and pathway databases
BioCyc BSP107806:BU204-MON; -.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00596; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005993; GMP_reduct1.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000235; GMP_reductase; 1.
TIGRFAMs TIGR01305; GMP_reduct_1; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS P57300.
Genome annotation databases
GeneID 1109647; -.
GenomeReviews BA000003_GR; BU204.
KEGG buc:BU204; -.
Phylogenomic databases
HOGENOM P57300; -.
Genome annotation databases
CMR P57300; BU204.
Other
ProtoNet P57300.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NADP; Oxidoreductase; Potassium.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   349  349     GMP reductase. PRO_0000093732
NP_BIND   108   131  24     NADP (By similarity). 
NP_BIND   216   239  24     NADP (By similarity). 
ACT_SITE   186   186        Thioimidate intermediate (By similarity). 
METAL   181   181        Potassium; via carbonyl oxygen (By similarity). 
METAL   183   183        Potassium; via carbonyl oxygen (By similarity). 
Sequence information
Length: 349 AA [This is the length of the unprocessed precursor] Molecular weight: 38320 Da [This is the MW of the unprocessed precursor] CRC64: D4D109BD6B493D72 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRIEEDIKLG FKDVLIRPKR SILKSRSQVN LARCFSFKYS ASIWSGIPII AANMDTIGTF 

        70         80         90        100        110        120 
EMVKSLSKFN ILTAVHKYYS FEEWKNFVCL SSKEILNHVI VSIGTSNIDF LKIKKIFLLS 

       130        140        150        160        170        180 
SELKYICIDV ANGYSEHIVS FLKLVRDYFP DKIICAGNVV TGEMVEELIL SGADIVKVGI 

       190        200        210        220        230        240 
GPGSVCTTRV KTGVGYPQLS AIIECADAAH GLNGQIISDG GCTVSGDIAK AFGGGADFVM 

       250        260        270        280        290        300 
LGGMLSGHKE CSGDIIEEKS KKYMIFYGMS SVSAMQRYEG KIAGYRASEG KTVKIPFRGG 

       310        320        330        340 
VDSTIRDILG GLRSSCTYVG AEKLKELTKR TTFIRVTEQE NCIFNAFKE
P57300 in FASTA format

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