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UniProtKB/Swiss-Prot entry P58837


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P1_METAC
Primary accession number P58837
Secondary accession numbers None
Integrated into Swiss-Prot on May 27, 2002
Sequence was last modified on May 27, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 50)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase 1
Synonyms GAPDH 1
EC 1.2.1.59
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase 1
Gene name
Name: gapA
OrderedLocusNames: MA_1018
From
Methanosarcina acetivorans [TaxID: 2214] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
DOI=10.1101/gr.223902; PubMed=11932238 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W., Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J., Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P., McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D., Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R., Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J., Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A., White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H., Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V., Zinder S.H., Lander E., Metcalf W.W., Birren B.;
"The genome of Methanosarcina acetivorans reveals extensive metabolic and physiological diversity.";
Genome Res. 12:532-542(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE010299; AAM04448.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_615968.1; -.
3D structure databases
HSSP P10618; 1CF2. [HSSP ENTRY / PDB]
ModBase P58837.
Enzyme and pathway databases
BioCyc MACE188937:MA1018-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00559; -; 1.
PBIL [Tree]
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006436; Glyceraldehyde-3-P_DHase_2_arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
ProDom PD007761; GAPDH_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01546; GAPDH-II_archae; 1.
PROSITE PS00071; GAPDH; 1.
BLOCKS P58837.
Genome annotation databases
GeneID 1472908; -.
GenomeReviews AE010299_GR; MA_1018.
KEGG mac:MA1018; -.
NMPDR fig|188937.1.peg.994; -.
Phylogenomic databases
HOGENOM P58837; -.
Genome annotation databases
CMR P58837; MA_1018.
Other
ProtoNet P58837.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Glyceraldehyde-3-phosphate dehydrogenase 1. PRO_0000145718
NP_BIND   13    14  2     NAD (By similarity). 
REGION   140   142  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   195   196  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   141   141        Nucleophile (By similarity). 
BINDING   111   111        NAD; via amide nitrogen (By similarity). 
BINDING   169   169        NAD (By similarity). 
BINDING   171   171        Glyceraldehyde 3-phosphate (By similarity). 
BINDING   300   300        NAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 36491 Da [This is the MW of the unprocessed precursor] CRC64: 53D34A317B1294C8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAKAKIAVNG YGTIGKRVAD AVKAQDDMEV VGISKRTPNY EAAVAHQLGY DIYAPAENVG 

        70         80         90        100        110        120 
AFEKAGMPAA GSVEEMIEKA DLVVDCTPGG VGEKNKPLYE KAGVKAIWQG GESHPIAGFS 

       130        140        150        160        170        180 
FNAVSNYEGA LGRDLVRVVS CNTTGLCRTI TPIDRELGVK KVRAILARRA TDPNDIKKGP 

       190        200        210        220        230        240 
INAIVLHPVK LPSHHGPDVR SVIPHINITS AALLVPTTLM HLHTVNMEVD TDCTAEDIKK 

       250        260        270        280        290        300 
IFSSQSRIRF IGQGITSTAE IMEVARDIKR PRNDMWENCI WPESITVDEK EFYFFQAIHQ 

       310        320        330 
ESIVVPENVD AIRAMMELES DGAKSIEKTN KALGM 

P58837 in FASTA format

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