ID   AROE_BUCBP              Reviewed;         282 AA.
AC   P59414;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2003, sequence version 1.
DT   25-NOV-2008, entry version 43.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=bbp_437;
OS   Buchnera aphidicola subsp. Baizongia pistaciae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=135842;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22426901; PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AE016826; AAO27143.1; -; Genomic_DNA.
DR   RefSeq; NP_778038.1; -.
DR   HSSP; P15770; 1NYT.
DR   GeneID; 1058638; -.
DR   GenomeReviews; AE016826_GR; bbp_437.
DR   KEGG; bab:bbp437; -.
DR   HOGENOM; P59414; -.
DR   BioCyc; BAPH224915:BBP_437-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR011342; Quinate/shikimate_5-DHase.
DR   InterPro; IPR013708; Shikimate_DHase-bd_N.
DR   InterPro; IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    282       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135997.
FT   NP_BIND     132    136       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   282 AA;  31975 MW;  344F5BDC826A9327 CRC64;
     MVKHCIDQFC VFGNPINHTQ SPYIHSLFSK QTGIVYEYSA RLVPFKEFNS YVLNFFLNKG
     KGANITVPFK ENAYVISNNL TIRAKMSRAV NTFKKLHNNK ILGDNTDGIG VLHDLKRIKF
     IKSKFNRVLL IGAGGAARGI IFSLLSYGCS IVVLNRTITR ALQLVEDFKN VGSISIFKEK
     FASNYSFNLI INATTINICQ NSNLSTIKSL IHKDVYCYDI NYSIKHKYTE FLLWCIKNGA
     ICVSNGIGML VSQAAHSFYL WYGILPETNS IICKLNRQFY ML
//