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UniProtKB/Swiss-Prot entry P60801

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDXB_SALTI
Primary accession number P60801
Secondary accession number Q8XGK3
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on April 13, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 35)
Name and origin of the protein
Protein name Erythronate-4-phosphate dehydrogenase
Synonym EC 1.1.1.290
Gene name
Name: pdxB
OrderedLocusNames: STY2601, t0494
From
Salmonella typhi [TaxID: 601] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CT18;
DOI=10.1038/35101607; PubMed=11677608 [NCBI, ExPASy, EBI, Israel, Japan]
Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J., Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M., Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
"Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.";
Nature 413:848-852(2001).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700931 / Ty2;
DOI=10.1128/JB.185.7.2330-2337.2003; PubMed=12644504 [NCBI, ExPASy, EBI, Israel, Japan]
Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
"Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.";
J. Bacteriol. 185:2330-2337(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL627274; CAD07602.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014613; AAO68200.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_456912.1; -.
NP_804351.1; -.
3D structure databases
ModBase P60801.
Enzyme and pathway databases
BioCyc SENT209261:T0494-MON; -.
SENT220341:STY2601-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0033711; Molecular function: 4-phosphoerythronate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0008615; Biological process: pyridoxine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01825; -; 1.
PBIL [Tree]
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; 1.
ProtoNet P60801.
Genome annotation databases
GeneID 1069439; -.
1248925; -.
GenomeReviews AL513382_GR; STY2601.
AE014613_GR; t0494.
KEGG stt:t0494; -.
sty:STY2601; -.
Phylogenomic databases
HOGENOM P60801; -.
Genome annotation databases
CMR P60801; STY2601.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; Oxidoreductase; Pyridoxine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   378  378     Erythronate-4-phosphate dehydrogenase. PRO_0000075985
ACT_SITE   208   208        By similarity. 
ACT_SITE   237   237        By similarity. 
ACT_SITE   254   254        Proton donor (By similarity). 
BINDING   45    45        Substrate (By similarity). 
BINDING   66    66        Substrate (By similarity). 
BINDING   146   146        NAD (By similarity). 
BINDING   175   175        NAD; via carbonyl oxygen (By similarity). 
BINDING   232   232        NAD (By similarity). 
BINDING   257   257        NAD; via amide nitrogen (By similarity). 
BINDING   258   258        Substrate (By similarity). 
Sequence information
Length: 378 AA [This is the length of the unprocessed precursor] Molecular weight: 41298 Da [This is the MW of the unprocessed precursor] CRC64: 365198C8CA796241 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKILVDENMP YARELFSRLG EVKAVPGRPI PVEELNHADA LMVRSVTKVN ESLLSGTPIN 

        70         80         90        100        110        120 
FVGTATAGTD HVDEAWLKQA GIGFSAAPGC NAIAVVEYVF SALLMLAERD GFSLRDRTIG 

       130        140        150        160        170        180 
IVGVGNVGSR LQTRLEALGI RTLLCDPPRA ARGDEGDFRT LDELVQEADV LTFHTPLYKD 

       190        200        210        220        230        240 
GPYKTLHLAD ETLIRRLKPG AILINACRGP VVDNAALLAR LNAGQPLSVV LDVWEGEPDL 

       250        260        270        280        290        300 
NVALLEAVDI GTSHIAGYTL EGKARGTTQV FEAYSAFIGR EQRVALETLL PAPEFGRITL 

       310        320        330        340        350        360 
HGPLDQPTLK RLAHLVYDVR RDDAPLRKVA GIPGEFDKLR KNYLERREWS SLYVMCDDET 

       370 
AAALLCKLGF NAVHHPAH
P60801 in FASTA format

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