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UniProtKB/Swiss-Prot entry P62349

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_PHOPR
Primary accession number P62349
Secondary accession numbers None
Integrated into Swiss-Prot on July 5, 2004
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: PBPRA1085
From
Photobacterium profundum (Photobacterium sp. (strain SS9)) [TaxID: 74109] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Photobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1103341; PubMed=15746425 [NCBI, ExPASy, EBI, Israel, Japan]
Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C., Bartlett D.H., Valle G.;
"Life at depth: Photobacterium profundum genome sequence and expression analysis.";
Science 307:1459-1461(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR378666; CAG19496.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_129298.1; -.
3D structure databases
ModBase P62349.
Enzyme and pathway databases
BioCyc PPRO298386:PBPRA1085-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
ProtoNet P62349.
Genome annotation databases
GeneID 3123515; -.
GenomeReviews CR354531_GR; PBPRA1085.
KEGG ppr:PBPRA1085; -.
NMPDR fig|298386.1.peg.3323; -.
Phylogenomic databases
HOGENOM P62349; -.
Genome annotation databases
CMR P62349; PBPRA1085.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   207  207     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136422
REGION   1   117  117     Phosphoribosyl-AMP cyclohydrolase. 
REGION   118   207  90     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 207 AA [This is the length of the unprocessed precursor] Molecular weight: 22815 Da [This is the MW of the unprocessed precursor] CRC64: 9963EADAC7D53DDD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLVTTINWE KVDGLVPAVI QDNTSGQVLM LGYMNKEALN KTLETKQVTF WSRTKERLWT 

        70         80         90        100        110        120 
KGETSGNVLE LKSINLDCDQ DTLLVKVNPV GPTCHLGTPT CFDNDAEGKQ EQPALVFLHQ 

       130        140        150        160        170        180 
LEQVLANRKG ADPESSYTAS LYARGTKRIS QKVGEEGVEV ALAATSGDKA ELVCESADLI 

       190        200 
YHLIVLLQDQ GLSLSDVTEK LQERHNK
P62349 in FASTA format

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