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UniProtKB/Swiss-Prot entry P64356

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_STAAN
Primary accession number P64356
Secondary accession number Q99QW9
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 25)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: SA2464
From
Staphylococcus aureus (strain N315) [TaxID: 158879] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(00)04403-2; PubMed=11418146 [NCBI, ExPASy, EBI, Israel, Japan]
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y., Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.;
"Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
Lancet 357:1225-1240(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000018; BAB43770.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H90075; H90075.
RefSeq NP_375791.1; -.
3D structure databases
ModBase P64356.
Enzyme and pathway databases
BioCyc SAUR158879:SA2464-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
ProtoNet P64356.
Genome annotation databases
GeneID 1125394; -.
GenomeReviews BA000018_GR; SA2464.
KEGG sau:SA2464; -.
Phylogenomic databases
HOGENOM P64356; -.
Genome annotation databases
CMR P64356; SA2464.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   210  210     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136432
REGION   1   106  106     Phosphoribosyl-AMP cyclohydrolase. 
REGION   107   210  104     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 210 AA [This is the length of the unprocessed precursor] Molecular weight: 23944 Da [This is the MW of the unprocessed precursor] CRC64: E8434D2FEE59B7CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKYKIDFSK GLVPAILQDN QTKQVLMLGY MNQEAFDKTI EDGVVCFYSR SKQRLWTKGE 

        70         80         90        100        110        120 
TSGHTQLVKD IHVDCDNDTI LIDVIPNGPT CHTGSQSCFN TEVPFSVQTL AQTVQDSAQS 

       130        140        150        160        170        180 
NNEKSYTKYL LTEGIEKITK KYGEEAFEVV IEAIKGDKKA FVSEVADELY HLFVLMHALG 

       190        200        210 
VDFSEIEAEL ARRHHKRNNF KGERQNIEQW
P64356 in FASTA format

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