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UniProtKB/Swiss-Prot entry P65529

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FPRB_MYCBO
Primary accession number P65529
Secondary accession number Q10547
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 27)
Name and origin of the protein
Protein name Probable ferredoxin/ferredoxin--NADP reductase
Synonyms FNR
EC 1.18.1.2
Gene name
Name: fprB
OrderedLocusNames: Mb0910
From
Mycobacterium bovis [TaxID: 1765] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-935 / AF2122/97;
DOI=10.1073/pnas.1130426100; PubMed=12788972 [NCBI, ExPASy, EBI, Israel, Japan]
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
"The complete genome sequence of Mycobacterium bovis.";
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX248336; CAD93771.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_854567.1; -.
3D structure databases
HSSP P03942; 1H98. [HSSP ENTRY / PDB]
ModBase P65529.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0004324; Molecular function: ferredoxin-NADP+ reductase activity (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004497; Molecular function: monooxygenase activity (inferred from electronic annotation from InterPro).
GO:0006725; Biological process: cellular aromatic compound metabolic process (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000813; 7Fe_ferredoxin.
IPR000759; Adrndx_reductase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR002938; mOase_FAD_bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01494; FAD_binding_3; 1.
PF00037; Fer4; 2.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00354; 7FE8SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet P65529.
Genome annotation databases
GeneID 1092796; -.
GenomeReviews BX248333_GR; Mb0910.
KEGG mbo:Mb0910; -.
Phylogenomic databases
HOGENOM P65529; -.
Genome annotation databases
CMR P65529; Mb0910.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Electron transport; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Repeat; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   575  575     Probable ferredoxin/ferredoxin--NADP reductase. PRO_0000167675
DOMAIN   2    29  28     4Fe-4S ferredoxin-type 1. 
DOMAIN   37    66  30     4Fe-4S ferredoxin-type 2. 
NP_BIND   258   261  4     NADP (By similarity). 
NP_BIND   302   303  2     NADP (By similarity). 
NP_BIND   463   465  3     FAD (By similarity). 
REGION   115   575  461     Ferredoxin--NADP reductase. 
METAL   9     9        Iron-sulfur 1 (By similarity). 
METAL   15    15        Iron-sulfur 1 (By similarity). 
METAL   19    19        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   46    46        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   49    49        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   52    52        Iron-sulfur 2 (4Fe-4S) (By similarity). 
METAL   56    56        Iron-sulfur 1 (By similarity). 
BINDING   123   123        FAD; via amide nitrogen (By similarity). 
BINDING   143   143        FAD (By similarity). 
BINDING   151   151        FAD; via amide nitrogen (By similarity). 
BINDING   187   187        FAD; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   213   213        NADP (By similarity). 
BINDING   314   314        NADP (By similarity). 
BINDING   456   456        FAD; via amide nitrogen (By similarity). 
BINDING   463   463        NADP; via amide nitrogen (By similarity). 
Sequence information
Length: 575 AA [This is the length of the unprocessed precursor] Molecular weight: 61337 Da [This is the MW of the unprocessed precursor] CRC64: 170C58599872A810 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPHVITQSCC NDASCVFACP VNCIHPTPDE PGFATSEMLY IDPVACVDCG ACVTACPVSA 

        70         80         90        100        110        120 
IAPNTRLDFE QLPFVEINAS YYPKRPAGVK LAPTSKLAPV TPAAEVRVRR QPLTVAVVGS 

       130        140        150        160        170        180 
GPAAMYAADE LLVQQGVQVN VFEKLPTPYG LVRSGVAPDH QNTKRVTRLF DRIAGHRRFR 

       190        200        210        220        230        240 
FYLNVEIGKH LGHAELLAHH HAVLYAVGAP DDRRLTIDGM GLPGTGTATE LVAWLNGHPD 

       250        260        270        280        290        300 
FNDLPVDLSH ERVVIIGNGN VALDVARVLA ADPHELAATD IADHALSALR NSAVREVVVA 

       310        320        330        340        350        360 
ARRGPAHSAF TLPELIGLTA GADVVLDPGD HQRVLDDLAI VADPLTRNKL EILSTLGDGS 

       370        380        390        400        410        420 
APARRVGRPR IRLAYRLTPR RVLGQRRAGG VQFSVTGTDE LRQLDAGLVL TSIGYRGKPI 

       430        440        450        460        470        480 
PDLPFDEQAA LVPNDGGRVI DPGTGEPVPG AYVAGWIKRG PTGFIGTNKS CSMQTVQALV 

       490        500        510        520        530        540 
ADFNDGRLTD PVATPTALDQ LVQARQPQAI GCAGWRAIDA AEIARGSADG RVRNKFTDVA 

       550        560        570 
EMLAAATSAP KEPLRRRVLA RLRDLGQPIV LTVPL
P65529 in FASTA format

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