ID   NUOC_MYCBO              Reviewed;         236 AA.
AC   P65572; P95179;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-NOV-2008, entry version 21.
DE   RecName: Full=NADH-quinone oxidoreductase subunit C;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit C;
DE   AltName: Full=NDH-1 subunit C;
GN   Name=nuoC; OrderedLocusNames=Mb3171;
OS   Mycobacterium bovis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   MEDLINE=22709107; PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA   Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA   Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA   Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be menaquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
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DR   EMBL; BX248345; CAD95263.1; -; Genomic_DNA.
DR   RefSeq; NP_856816.1; -.
DR   GeneID; 1093222; -.
DR   GenomeReviews; BX248333_GR; Mb3171.
DR   KEGG; mbo:Mb3171; -.
DR   HOGENOM; P65572; -.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to u...; IEA:InterPro.
DR   InterPro; IPR010218; NADH_DH_csu.
DR   InterPro; IPR001268; NADH_DHase_Ub_30kDa_su.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   ProDom; PD001581; Complex1_30K; 1.
DR   TIGRFAMs; TIGR01961; NuoC_fam; 1.
DR   PROSITE; PS00542; COMPLEX1_30K; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase; Quinone.
FT   CHAIN         1    236       NADH-quinone oxidoreductase subunit C.
FT                                /FTId=PRO_0000118671.
SQ   SEQUENCE   236 AA;  26932 MW;  251014470CA32BA6 CRC64;
     MSPPNQDAQE GRPDSPTAEV VDVRRGMFGV SGTGDTSGYG RLVRQVVLPG SSPRPYGGYF
     DDIVDRLAEA LRHERVEFED AVEKVVVYRD ELTLHVRRDL LPRVAQRLRD EPELRFELCL
     GVSGVHYPHE TGRELHAVYP LQSITHNRRL RLEVSAPDSD PHIPSLFAIY PTNDWHERET
     YDFFGIIFDG HPALTRIEMP DDWQGHPQRK DYPLGGIPVE YKGAQIPPPD ERRGYN
//