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UniProtKB/Swiss-Prot entry P65635

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ODP2_STAAM
Primary accession number P65635
Secondary accession number Q99V06
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 30)
Name and origin of the protein
Protein name Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Synonyms EC 2.3.1.12
E2
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Gene name
Name: pdhC
OrderedLocusNames: SAV1095
From
Staphylococcus aureus (strain Mu50 / ATCC 700699) [TaxID: 158878] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(00)04403-2; PubMed=11418146 [NCBI, ExPASy, EBI, Israel, Japan]
Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y., Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K.;
"Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
Lancet 357:1225-1240(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000017; BAB57257.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_371619.1; -.
3D structure databases
HSSP P11961; 2PDE. [HSSP ENTRY / PDB]
SMR P65635; 2-79, 121-165.
ModBase P65635.
Enzyme and pathway databases
BioCyc SAUR158878:SAV1095-MON; -.
2D gel databases
World-2DPAGE 0002:P65635; -.
Ontologies
GO
GO:0004742; Molecular function: dihydrolipoyllysine-residue acetyltransferase activity (inferred from electronic annotation from EC).
GO:0031405; Molecular function: lipoic acid binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003016; 2-oxoA_DHase_lipoyl-BS.
IPR001078; 2Oxoacid_DHase.
IPR000089; Biotin_lipoyl.
IPR004167; E3_bd.
Graphical view of domain structure.
Gene3D G3DSA:4.10.320.10; E3_bd; 1.
Pfam PF00198; 2-oxoacid_dh; 1.
PF00364; Biotin_lipoyl; 1.
PF02817; E3_binding; 1.
Pfam graphical view of domain structure.
ProDom PD001115; 2Oxoacid_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS50968; BIOTINYL_LIPOYL; 1.
PS00189; LIPOYL; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P65635.
Genome annotation databases
GeneID 1121072; -.
GenomeReviews BA000017_GR; SAV1095.
KEGG sav:SAV1095; -.
Phylogenomic databases
HOGENOM P65635; -.
Genome annotation databases
CMR P65635; SAV1095.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Complete proteome; Glycolysis; Lipoyl; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   430  430     Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. PRO_0000162288
DOMAIN   1    76  76     Lipoyl-binding. 
ACT_SITE   401   401        Potential. 
BINDING   43    43        Lipoyl (covalent) (By similarity). 
Sequence information
Length: 430 AA [This is the length of the unprocessed precursor] Molecular weight: 46368 Da [This is the MW of the unprocessed precursor] CRC64: 4050074CAE5ACDA4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFEFRLPDI GEGIHEGEIV KWFVKAGDTI EEDDVLAEVQ NDKSVVEIPS PVSGTVEEVM 

        70         80         90        100        110        120 
VEEGTVAVVG DVIVKIDAPD AEDMQFKGHD DDSSSKEEPA KEEAPAEQAP VATQTEEVDE 

       130        140        150        160        170        180 
NRTVKAMPSV RKYAREKGVN IKAVSGSGKN GRITKEDVDA YLNGGAPTAS NESAASATSE 

       190        200        210        220        230        240 
EVAETPAAPA AVSLEGDFPE TTEKIPAMRR AIAKAMVNSK HTAPHVTLMD EIDVQALWDH 

       250        260        270        280        290        300 
RKKFKEIAAE QGTKLTFLPY VVKALVSALK KYPALNTSFN EEAGEIVHKH YWNIGIAADT 

       310        320        330        340        350        360 
DRGLLVPVVK HADRKSIFQI SDEINELAVK ARDGKLTADE MKGATCTISN IGSAGGQWFT 

       370        380        390        400        410        420 
PVINHPEVAI LGIGRIAQKP IVKDGEIVAA PVLALSLSFD HRQIDGATGQ NAMNHIKRLL 

       430 
NNPELLLMEG
P65635 in FASTA format

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