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UniProtKB/Swiss-Prot entry P65681

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PDXA_BRUSU
Primary accession number P65681
Secondary accession number P58712
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 28)
Name and origin of the protein
Protein name 4-hydroxythreonine-4-phosphate dehydrogenase
Synonyms EC 1.1.1.262
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene name
Name: pdxA
OrderedLocusNames: BR0683
From
Brucella suis [TaxID: 29461] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1330 / Biovar 1;
DOI=10.1073/pnas.192319099; PubMed=12271122 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.";
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014291; AAN29612.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_697697.1; -.
3D structure databases
ModBase P65681.
Enzyme and pathway databases
BioCyc BSUI204722:BR_0683-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0050570; Molecular function: 4-hydroxythreonine-4-phosphate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0050897; Molecular function: cobalt ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008615; Biological process: pyridoxine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00536; -; 1.
PBIL [Tree]
InterPro IPR005255; PyrdxlP_synth_PdxA.
Graphical view of domain structure.
Pfam PF04166; PdxA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00557; pdxA; 1.
ProtoNet P65681.
Genome annotation databases
GeneID 1166346; -.
GenomeReviews AE014291_GR; BR0683.
KEGG bms:BR0683; -.
TIGR BR0683; -.
Phylogenomic databases
HOGENOM P65681; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cobalt; Complete proteome; Cytoplasm; Magnesium; Metal-binding; NAD; NADP; Oxidoreductase; Pyridoxine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   343  343     4-hydroxythreonine-4-phosphate dehydrogenase. PRO_0000188801
METAL   176   176        Divalent metal cation; shared with dimeric partner (By similarity). 
METAL   221   221        Divalent metal cation; shared with dimeric partner (By similarity). 
METAL   276   276        Divalent metal cation; shared with dimeric partner (By similarity). 
BINDING   141   141        Substrate (By similarity). 
BINDING   142   142        Substrate (By similarity). 
BINDING   284   284        Substrate (By similarity). 
BINDING   293   293        Substrate (By similarity). 
BINDING   302   302        Substrate (By similarity). 
Sequence information
Length: 343 AA [This is the length of the unprocessed precursor] Molecular weight: 36193 Da [This is the MW of the unprocessed precursor] CRC64: FBF6CA0AB6D28617 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRAKPLPPLA VSIGDPSGIG ADVALAAWLK RCELSLPPFF LIADPKQLAA RARHLGLAVD 

        70         80         90        100        110        120 
FAILSDPREA EAAFGERLPL LALKHSHTES PGKPLTENAA GVIEAIERAV ELTLKGEAAA 

       130        140        150        160        170        180 
VVTCPIAKKP LYEAGFQHPG HTEFLAELAG HHLGKPVTPV MMLAGPQLRA VPVTIHIPLS 

       190        200        210        220        230        240 
EVPARLTTTE IVAVSRITAN ELRERFGIAS PRLAISGLNP HAGEGGALGK EDDAIILPAI 

       250        260        270        280        290        300 
EQLIREGIDA RGPLPADTMF HAPARATYDA AICMYHDQAL IPAKALAFDE TVNVTLGLPF 

       310        320        330        340 
IRTSPDHGTA FDIAGKGIAR PDSLVAAMRL AQQLAENAAS RNA
P65681 in FASTA format

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