[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=71; Calcutt M.J., Lewis M.S., Eisenstark A.; Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)⁺ = 5,10-methylenetetrahydrofolate + NAD(P)H.
COFACTOR: FAD (By similarity).
PATHWAY: One-carbon metabolism; tetrahydrofolate pathway .
SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.

Copyright

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Cross-references

Sequence databases

EMBL

U74302; AAC72242.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00394; 1B5T. [HSSP ENTRY / PDB]

SMR

P71319; 3-294.

ModBase

P71319.

Family and domain databases

InterPro

IPR003171; Mehydrof_redctse.
IPR004620; MTHF_reductase_bac.
Graphical view of domain structure.

Pfam

PF02219; MTHFR; 1.
Pfam graphical view of domain structure.

TIGR00676; fadh2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; FAD; Flavoprotein; Methionine biosynthesis; NAD; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 298`	`298`		`5,10-methylenetetrahydrofolate reductase.`	`PRO_0000190262`

Sequence information

Length: 298 AA [This is the length of the unprocessed precursor]

Molecular weight: 33589 Da [This is the MW of the unprocessed precursor]

CRC64: 50FE729E4E3E2C56 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSFFHANQRE ALNQSLAELQ GRINVSFEFF PPRTSDMEET LWSSIDRLSS LKPKFVSVTY 

        70         80         90        100        110        120 
GANSGERDRT HSIIKTIKER TGLEAAPHLT CIDASREQLR EIAQDYWESG IRHIVALRGD 

       130        140        150        160        170        180 
LPQEGGKPDM YAADLVSLLK EVGDFDISVA AYPEVHPEAK SAQADLINLK HKIDAGANRA 

       190        200        210        220        230        240 
ITQFFFDVES YLRFRDRCVA TGIDVEIVPG ILPVSNFKQL QKFATMTNVR VPNWMTTMFD 

       250        260        270        280        290 
GLDNDPETRK MVGASIAMDM VKILSREGVK DFHFYTLNRA ELSYAICHTL GVRPDVAR

P71319 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools