NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/dnares/3.3.109; PubMed=8905231 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.";
DNA Res. 3:109-136(1996).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000022; BAA18679.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S76767; S76767.

RefSeq

NP_442867.1; -.

3D structure databases

ModBase

P74572.

Enzyme and pathway databases

BioCyc

SSP1148:SLR0661-MON; -.

Family and domain databases

InterPro

IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

GeneID

952360; -.

GenomeReviews

BA000022_GR; slr0661.

KEGG

syn:slr0661; -.

NMPDR

fig|1148.1.peg.2968; -.

Phylogenomic databases

HOGENOM

P74572; -.

Genome annotation databases

CMR

P74572; slr0661.

Other

ProtoNet

P74572.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 267`	`267`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187308`

Sequence information

Length: 267 AA [This is the length of the unprocessed precursor]

Molecular weight: 27883 Da [This is the MW of the unprocessed precursor]

CRC64: FD9C428047F391B0 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSIQLGIIGG GVMAEAILAR LIAEKTYAPE EIIVGEPHGA RRDYLQKTYQ VRVSPDNQEA 

        70         80         90        100        110        120 
ANVSEVLLLA VKPQVLDRVL ASLAGGANRP LVISILAGVS LQRIQKGFPD HAIIRAMPNT 

       130        140        150        160        170        180 
PATVGAGMTA IAANKMVEPD QLAKAKAIFS AVGNVVEVPE NLMDAVTGVS GSGPAYVALM 

       190        200        210        220        230        240 
IEALADGGVL AGLPRAIAQK LALQTVLGTA ELIKETEEHP AQIKDKVTSP GGTTIAGVAV 

       250        260 
LEKMGFRSAI IEAVRAAYRR SQELGKK

P74572 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools