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- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
- COFACTOR: Thiamine pyrophosphate (By similarity).
- SUBUNIT: Heterodimer of an alpha and a beta chain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 358 AA [This is the length of the unprocessed precursor] |
Molecular weight: 40594 Da [This is the MW of the unprocessed precursor] |
CRC64: E6184A2026D7A143 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAILIKNKVP TTLYQVYDNE GKLMDPNHKI TLSNEQLKHA FYLMNLSRIM DKKMLVWQRA
70 80 90 100 110 120
GKMLNFAPNL GEEALQVGMG MGLNENDWFC PTFRSGALML YRGVKPEQLL LYWNGNENGS
130 140 150 160 170 180
KIEAKYKTLP INITIGAQYS HAAGLGYMLH YKKLPNVAVT MIGDGGTAEG EFYEAMNIAS
190 200 210 220 230 240
IHKWNSVFCI NNNQFAISTR TKLESAVSDL STKAIAVNIP RIRVDGNDLI ASYEAMHEAA
250 260 270 280 290 300
NYARSGNGPV LIEFFSWRQG PHTTSDDPSI YRTKEEEAEA MKSDPVKRLR NFLFDRGILT
310 320 330 340 350
PQQEEEMVAK IEQEVQAAYE VMVSKTPVTL DEVFDYNYEK LTPDLARQKA EAKKYFKD
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P75390 in FASTA format |
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