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UniProtKB/Swiss-Prot entry P77161


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GLXR_ECOLI
Primary accession number P77161
Secondary accession number Q2MBR9
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on February 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 65)
Name and origin of the protein
Protein name 2-hydroxy-3-oxopropionate reductase
Synonyms EC 1.1.1.60
Tartronate semialdehyde reductase
TSAR
Gene name
Name: glxR
Synonyms: glxB1, ybbQ
OrderedLocusNames: b0509, JW0497
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=K12 / ECL1;
PubMed=10601204 [NCBI, ExPASy, EBI, Israel, Japan]
Cusa E., Obradors N., Baldoma L., Badia J., Aguilar J.;
"Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.";
J. Bacteriol. 181:7479-7484(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
"Sequence of minutes 4-25 of Escherichia coli.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U89279; AAB93851.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U82664; AAB40262.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC73611.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE76287.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D64782; D64782.
RefSeq AP_001157.1; -.
NP_415042.1; -.
3D structure databases
SMR P77161; 1-291.
ModBase P77161.
Protein-protein interaction databases
IntAct P77161; -.
Enzyme and pathway databases
BioCyc EcoCyc:G6278-MON; -.
MetaCyc:G6278-MON; -.
Organism-specific databases
EchoBASE EB3052; -.
EcoGene EG13265; glxR.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006183; 6-phosphogluconate_DHase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR006398; Tartro_sem_red.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00076; 6PGDHDRGNASE.
TIGRFAMs TIGR01505; tartro_sem_red; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
BLOCKS P77161.
Genome annotation databases
GeneID 945146; -.
GenomeReviews U00096_GR; b0509.
AP009048_GR; JW0497.
KEGG ecj:JW0497; -.
eco:b0509; -.
Phylogenomic databases
HOGENOM P77161; -.
Genome annotation databases
CMR P77161; b0509.
Other
ProtoNet P77161.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   292  292     2-hydroxy-3-oxopropionate reductase. PRO_0000173061
ACT_SITE   169   169        By similarity. 
Sequence information
Length: 292 AA [This is the length of the unprocessed precursor] Molecular weight: 30801 Da [This is the MW of the unprocessed precursor] CRC64: 5D5263231F2910F0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR QVTEASDIIF 

        70         80         90        100        110        120 
IMVPDTPQVE EVLFGENGCT KASLKGKTIV DMSSISPIET KRFARQVNEL GGDYLDAPVS 

       130        140        150        160        170        180 
GGEIGAREGT LSIMVGGDEA VFERVKPLFE LLGKNITLVG GNGDGQTCKV ANQIIVALNI 

       190        200        210        220        230        240 
EAVSEALLFA SKAGADPVRV RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN 

       250        260        270        280        290 
LALQSAKALA LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA 

P77161 in FASTA format

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