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UniProtKB/Swiss-Prot entry P77915

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEMN_PSEAE
Primary accession number P77915
Secondary accession numbers Q04626 Q04627
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on December 8, 2000 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 59)
Name and origin of the protein
Protein name Oxygen-independent coproporphyrinogen III oxidase
Synonyms Coproporphyrinogenase
Coprogen oxidase
EC 1.3.99.22
Gene name
Name: hemN
OrderedLocusNames: PA1546
From
Pseudomonas aeruginosa [TaxID: 287] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
PubMed=9767567 [NCBI, ExPASy, EBI, Israel, Japan]
Rompf A., Hungerer C., Hoffmann T., Lindenmeyer M., Romling U., Gross U., Doss M.O., Arai H., Igarashi Y., Jahn D.;
"Regulation of Pseudomonas aeruginosa hemF and hemN by the dual action of the redox response regulators Anr and Dnr.";
Mol. Microbiol. 29:985-997(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
DOI=10.1038/35023079; PubMed=10984043 [NCBI, ExPASy, EBI, Israel, Japan]
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.";
Nature 406:959-964(2000).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
Savioz A., Zimmermann A., Haas D.;
"RpoN-independent promoters having a conserved GG-N10-GC motif in Pseudomonas aeruginosa.";
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X97981; CAA66617.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE004091; AAG04935.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M98276; AAA25710.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M98276; AAA25711.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X57736; CAA40903.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X57736; CAA40904.1; ALT_FRAME; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A83454; A83454.
RefSeq NP_250237.1; -.
3D structure databases
ModBase P77915.
Enzyme and pathway databases
BioCyc PAER208964:PA1546-MON; -.
Organism-specific databases
PseudoCAP PA1546; -.
Family and domain databases
InterPro IPR006638; Elp3/MiaB/NifB.
IPR004558; HemN.
IPR010723; HemN_C.
IPR007197; Radical_SAM.
Graphical view of domain structure.
Pfam PF06969; HemN_C; 1.
PF04055; Radical_SAM; 1.
Pfam graphical view of domain structure.
SMART SM00729; Elp3; 1.
SMART graphical view of domain structure.
TIGRFAMs TIGR00538; hemN; 1.
BLOCKS P77915.
Genome annotation databases
GeneID 883053; -.
GenomeReviews AE004091_GR; PA1546.
KEGG pae:PA1546; -.
Phylogenomic databases
HOGENOM P77915; -.
Genome annotation databases
CMR P77915; PA1546.
Other
ProtoNet P77915.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; Cytoplasm; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Porphyrin biosynthesis; S-adenosyl-L-methionine.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   460  460     Oxygen-independent coproporphyrinogen III oxidase. PRO_0000109947
REGION   115   116  2     S-adenosyl-L-methionine 2 binding (By similarity). 
METAL   63    63        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   67    67        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
METAL   70    70        Iron-sulfur (4Fe-4S-S-AdoMet) (By similarity). 
BINDING   57    57        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   69    69        S-adenosyl-L-methionine 2; via carbonyl oxygen (By similarity). 
BINDING   114   114        S-adenosyl-L-methionine 1; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   149   149        S-adenosyl-L-methionine 1 (By similarity). 
BINDING   176   176        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   188   188        S-adenosyl-L-methionine 2 (By similarity). 
BINDING   213   213        S-adenosyl-L-methionine 2 (By similarity). 
CONFLICT   104   104        E -> A (in Ref. 1 and 3). 
CONFLICT   422   422        L -> P (in Ref. 1; CAA66617). 
Sequence information
Length: 460 AA [This is the length of the unprocessed precursor] Molecular weight: 52488 Da [This is the MW of the unprocessed precursor] CRC64: A15EFD0FD04AB03E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLDTIRWDAD LIRRYDLSGP RYTSYPTAVQ FHEGIGPFDQ LHALRDSRKA GHPLSLYVHI 

        70         80         90        100        110        120 
PFCANICYYC ACNKVITKDR GRSAPYLARL VREIEIVSRH LSREQVVEQL HFGGGTPTFL 

       130        140        150        160        170        180 
SPGQLRELMS QLRTHLNLLD DDSGDYGIEI DPREADWSTM GLLRELGFNR VSLGVQDFDM 

       190        200        210        220        230        240 
EVQKAVNRMQ TPEETRTIVE AARTLQYRSI NLDLIYGLPK QTPDSFARTV DEVIALQPDR 

       250        260        270        280        290        300 
LSVFNYAHLP ERFMPQRRIN ADDLPSPGQK LEMLQRTTEQ LAAAGYRYIG MDHFALPDDE 

       310        320        330        340        350        360 
LASAQEDGTL QRNFQGYTTH GHCDLVGLGV SAISQIGDLY SQNSSDINDY QTSLDNGQLA 

       370        380        390        400        410        420 
IRRGLHCNSD DRVRRAVIQQ LICHFELAFE DIETEFGIDF RSYFAELWPD LERFAADGLI 

       430        440        450        460 
RLDAKGIDIT SSGRLLVRSI CMLFDRYLPS LNRQRFSRVI
P77915 in FASTA format

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