NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Liver;
DOI=10.1074/jbc.272.10.6766; PubMed=9045710 [NCBI, ExPASy, EBI, Israel, Japan]
Reuber B.E., Karl C., Reimann S.A., Mihalik S.J., Dodt G.;
"Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase.";
J. Biol. Chem. 272:6766-6776(1997).

Comments

FUNCTION: Metabolizes sarcosine, L-pipecolic acid and L-proline.
CATALYTIC ACTIVITY: Sarcosine + H₂O + O₂ = glycine + formaldehyde + H₂O₂.
CATALYTIC ACTIVITY: L-pipecolate + O₂ = 2,3,4,5-tetrahydropyridine-2-carboxylate + H₂O₂.
COFACTOR: Binds 1 FAD per subunit.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Peroxisome.
TISSUE SPECIFICITY: Kidney and liver.
SIMILARITY: Belongs to the MSOX/MTOX family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U82267; AAB48443.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001075851.1; -.

UniGene

Ocu.2126

3D structure databases

HSSP

P40859; 1EL5. [HSSP ENTRY / PDB]

ModBase

P79371.

Family and domain databases

InterPro

IPR006076; FAD-dep_OxRdtase.
IPR006281; SoxA_mon.
Graphical view of domain structure.

Pfam

PF01266; DAO; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01377; soxA_mon; 1.

BLOCKS

P79371.

Genome annotation databases

GeneID

100009239; -.

Phylogenomic databases

HOVERGEN

P79371; -.

Other

ProtoNet

P79371.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Oxidoreductase; Peroxisome.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 390`	`390`	`Peroxisomal sarcosine oxidase.`	`PRO_0000213775`
`NP_BIND`	`9 39`	`31`	`FAD (Potential).`
`MOTIF`	`388 390`	`3`	`Microbody targeting signal (Potential).`
`MOD_RES`	`319 319`		`S-8alpha-FAD cysteine (Probable).`

Sequence information

Length: 390 AA [This is the length of the unprocessed precursor]

Molecular weight: 44122 Da [This is the MW of the unprocessed precursor]

CRC64: E8715FEB607A4335 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAQKDLWDA IVIGAGIQGC FTVYHLVKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 

        70         80         90        100        110        120 
EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 

       130        140        150        160        170        180 
SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 

       190        200        210        220        230        240 
GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 

       250        260        270        280        290        300 
QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 

       310        320        330        340        350        360 
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 

       370        380        390 
LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

P79371 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools