[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, AND RNA EDITING. TISSUE=Tuber; DOI=10.1093/nar/22.16.3304; PubMed=8078764 [NCBI, ExPASy, EBI, Israel, Japan] Grohmann L., Thieck O., Herz U., Schroeder W., Brennicke A.; "Translation of nad9 mRNAs in mitochondria from Solanum tuberosum is restricted to completely edited transcripts."; Nucleic Acids Res. 22:3304-3311(1994).
[2]	PROTEIN SEQUENCE OF 1-17. STRAIN=cv. Bintje; TISSUE=Tuber; PubMed=8294484 [NCBI, ExPASy, EBI, Israel, Japan] Herz U., Schroeder W., Liddell A., Leaver C.J., Brennicke A., Grohmann L.; "Purification of the NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of Solanum tuberosum."; J. Biol. Chem. 269:2263-2269(1994).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBUNIT: Complex I is composed of about 30 different subunits.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
RNA EDITING: Modified_positions=31, 56, 100, 110, 122, 133, 147.
SIMILARITY: Belongs to the complex I 30 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X79774; CAA56168.1; ALT_SEQ; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S48062; S48062.

3D structure databases

ModBase

P80261.

Family and domain databases

InterPro

IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
Graphical view of domain structure.

Pfam

PF00329; Complex1_30kDa; 1.
Pfam graphical view of domain structure.

ProDom

PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01961; NuoC_fam; 1.

PROSITE

PS00542; COMPLEX1_30K; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; RNA editing; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 190`	`190`		`NADH-ubiquinone oxidoreductase 27 kDa subunit.`	`PRO_0000118643`

Sequence information

Length: 190 AA [This is the length of the unprocessed precursor]

Molecular weight: 22883 Da [This is the MW of the unprocessed precursor]

CRC64: A150CF461B493A53 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDNQFIFKYS WETLPKKWVK KMERSEHGNR FDTNTDYLFQ LLCFMKLHTY TRVQVLIDIC 

        70         80         90        100        110        120 
GVDYPSRKQR FEVVYNLLSI RYNSRIRVQT SADEVTRISS VVSLFPSAGW WEREVWDMFG 

       130        140        150        160        170        180 
VFSINHPDLR RILTDYGFEG HPLRKDFPLS GYVEVRYDDP EKRVVSEPIE MTQEFRYFDF 

       190 
ASPWEQRSDG

P80261 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools