NUCLEOTIDE SEQUENCE.
DOI=10.1073/pnas.93.6.2328; PubMed=8637872 [NCBI, ExPASy, EBI, Israel, Japan]
Burger G., Lang B.F., Reith M., Gray M.W.;
"Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes.";
Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases
HSSP	P07014; 1NEK. [HSSP ENTRY / PDB]
ModBase	P80477.
Family and domain databases
InterPro	IPR006058; 2Fe2S_fd_BS. IPR001450; 4Fe4S_Fe_S_bd. IPR012675; b-grasp_ferredoxin-like. IPR001041; Ferredoxin. IPR012285; Fum_reductase_C. IPR004489; Succ_DHase/fum_Rdtase_Fe-S. Graphical view of domain structure.
Gene3D	G3DSA:3.10.20.30; Ferredoxin_fold; 1. G3DSA:1.10.1060.10; Fum_reductase_C; 1.
Pfam	PF00111; Fer2; 1. Pfam graphical view of domain structure.
TIGRFAMs	TIGR00384; dhsB; 1.
PROSITE	PS00197; 2FE2S_FER_1; 1. PS51085; 2FE2S_FER_2; 1. PS00198; 4FE4S_FER_1; 1. PS51379; 4FE4S_FER_2; 1. PROSITE graphical view of domain structure (profiles).
BLOCKS	P80477.
Other
ProtoNet	P80477.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 239`	`239`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit.`	`PRO_0000158696`
`DOMAIN`	`24 99`	`76`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`142 172`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`63 63`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`68 68`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`71 71`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`83 83`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`152 152`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`155 155`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`158 158`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`162 162`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`209 209`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`215 215`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`219 219`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`167 167`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 239 AA [This is the length of the unprocessed precursor]

Molecular weight: 27301 Da [This is the MW of the unprocessed precursor]

CRC64: 5209A3754CAC3E20 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRPRNNNLNL KFIRIYRWTP SNQAEAKFSV HPIHTSNCGP MILDALIKIK DEQDSSLAFR 

        70         80         90        100        110        120 
RSCREGICGS CSMNIDGINT LACLKPIKTN ANIITIYPLP HMYIIKDLVP DLSNFFSQYK 

       130        140        150        160        170        180 
YIKPWLINNV PKKSEYLQSE KDRSELNGIY ECILCACCSA SCPSYWWNHD KYLGPAILLQ 

       190        200        210        220        230 
AYRWLADSRD TNAKERLKLL GGKSKLFKCH TIMNCSRTCP KSLNPGKAIA SIKHSINYS

P80477 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools