NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 50394;
DOI=10.1073/pnas.93.6.2328; PubMed=8637872 [NCBI, ExPASy, EBI, Israel, Japan]
Burger G., Lang B.F., Reith M., Gray M.W.;
"Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes.";
Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF007261; AAD11913.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S78180; S78180.

RefSeq

NP_044798.1; -.

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

ModBase

P80480.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

P80480.

Genome annotation databases

GeneID

801067; -.

Other

ProtoNet

P80480.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 239`	`239`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit.`	`PRO_0000158697`
`DOMAIN`	`11 100`	`90`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`141 171`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`61 61`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`66 66`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`69 69`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`81 81`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`151 151`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`154 154`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`157 157`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`161 161`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`208 208`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`214 214`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`218 218`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`166 166`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 239 AA [This is the length of the unprocessed precursor]

Molecular weight: 27828 Da [This is the MW of the unprocessed precursor]

CRC64: 781C6FF0ED55375B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNTKKEKIML FKVYRWNPDK KEKPHISTYS VDLNSCGPMV LDALIKIKNE QDSTLTFRRS 

        70         80         90        100        110        120 
CREGVCGSCA MNIDGTNTLA CIKSIDTNKK EMKIYPLPHM HIIKDLVPDL SNFYAQYKSI 

       130        140        150        160        170        180 
EPWMKTTEKK LDKEFYQSRN DREKLDGLYE CVLCACCSTS CPSYWWNSDK YLGPAVLLQA 

       190        200        210        220        230 
YRWIVDSRDQ GTRERLQYLE DPFKLYRCHT ILNCTKTCPK HLNPAQAIAK IKQNITLLT

P80480 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools