[1]	PROTEIN SEQUENCE. PubMed=8944761 [NCBI, ExPASy, EBI, Israel, Japan] Oppermann U.C.T., Maser E.; "Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the Gram-negative bacterium Comamonas testosteroni."; Eur. J. Biochem. 241:744-749(1996).

Comments

FUNCTION: Along with the 3 alpha-hydroxysteroid dehydrogenase and 3-oxo-reductase activities towards a variety of cis or trans fused A/B ring steroids, it also reduces several xenobiotic carbonyl compounds, including a metyrapone-based class of insecticides, to the respective alcohol metabolites.
CATALYTIC ACTIVITY: Androsterone + NAD(P)⁺ = 5-alpha-androstane-3,17-dione + NAD(P)H.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases
ModBase	P80701.
Family and domain databases
InterPro	IPR002198; DHase_sc/Rdtase_SDR. Graphical view of domain structure.
PROSITE	PS00061; ADH_SHORT; PARTIAL.
BLOCKS	P80701.
Other
ProtoNet	P80701.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >15`	`>15`	`3-alpha-hydroxysteroid dehydrogenase.`	`PRO_0000054657`
`REGION`	`6 >15`	`>10`	`Involved in cofactor binding (By similarity).`
`NON_TER`	`15 15`

Sequence information

Length: 15 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 1315 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 9506860D070A7790 [This is a checksum on the sequence]

        10 
QVIAITGSAS GIGAA

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools