[1]	PROTEIN SEQUENCE. PubMed=9108258 [NCBI, ExPASy, EBI, Israel, Japan] Tersteegen A., Linder D., Thauer R.K., Hedderich R.; "Structures and functions of four anabolic 2-oxoacid oxidoreductases in Methanobacterium thermoautotrophicum."; Eur. J. Biochem. 244:862-868(1997).

Comments

CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO₂ + 2 reduced ferredoxin + H⁺.
COFACTOR: Binds 2 4Fe-4S clusters (By similarity).
BIOPHYSICOCHEMICAL PROPERTIES:

pH dependence: Optimum pH is 9.7;
Temperature dependence: Optimum temperature is 75 degrees Celsius;
SUBUNIT: Heterotrimer of the vorA, vorB and vorC subunits.
SIMILARITY: Contains at least 1 4Fe-4S ferredoxin-type domain.

Copyright

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Cross-references

3D structure databases
ModBase	P80909.
Family and domain databases
InterPro	IPR001450; 4Fe4S_Fe_S_bd. Graphical view of domain structure.
PROSITE	PS00198; 4FE4S_FER_1; PARTIAL. PS51379; 4FE4S_FER_2; FALSE_NEG. PROSITE graphical view of domain structure (profiles).
BLOCKS	P80909.
Other
ProtoNet	P80909.
UniRef	View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Repeat; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >24`	`>24`	`Ketoisovalerate oxidoreductase subunit vorC.`	`PRO_0000099960`
`DOMAIN`	`4 >24`	`>21`	`4Fe-4S ferredoxin-type.`
`METAL`	`13 13`		`Iron-sulfur 1 (4Fe-4S) (Potential).`
`METAL`	`16 16`		`Iron-sulfur 1 (4Fe-4S) (Potential).`
`METAL`	`19 19`		`Iron-sulfur 1 (4Fe-4S) (Potential).`
`UNSURE`	`13 13`
`UNSURE`	`16 16`
`UNSURE`	`19 19`
`NON_TER`	`24 24`

Sequence information

Length: 24 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 2748 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 6E3CA79596800DC9 [This is a checksum on the sequence]

        10         20 
MKKAYPVINR VECXACERCI IQAP

P80909 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools