PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, AND SUBCELLULAR LOCATION.
STRAIN=cv. Romano;
TISSUE=Tuber;
DOI=10.1042/0264-6021:3430327; PubMed=10510296 [NCBI, ExPASy, EBI, Israel, Japan]
Millar A.H., Hill S.A., Leaver C.J.;
"Plant mitochondrial 2-oxoglutarate dehydrogenase complex: purification and characterization in potato.";
Biochem. J. 343:327-334(1999).

Comments

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion membrane.
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

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Cross-references

3D structure databases

Ontologies

GO:0031966;	Cellular component: mitochondrial membrane (inferred from direct assay from UniProtKB).
GO:0004591;	Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from direct assay from UniProtKB).
GO:0006091;	Biological process: generation of precursor metabolites and energy (inferred from direct assay from UniProtKB).
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Family and domain databases

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Glycolysis; Membrane; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >19`	`>19`	`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000238928`
`NON_TER`	`19 19`

Sequence information

Length: 19 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 2024 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 3AB2C6910C61EEF7 [This is a checksum on the sequence]

        10 
AQAAPVPRPV XLSKKTDSF

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools