[1]	PROTEIN SEQUENCE, CATALYTIC ACTIVITY, AND MASS SPECTROMETRY. STRAIN=N3H; DOI=10.1016/j.pep.2004.03.001; PubMed=15177292 [NCBI, ExPASy, EBI, Israel, Japan] Zamocky M., Godocikova J., Gasperik J., Koller F., Polek B.; "Expression, purification, and sequence analysis of catalase-1 from the soil bacterium Comamonas terrigena N3H."; Protein Expr. Purif. 36:115-123(2004).
[2]	CATALYTIC ACTIVITY, COFACTOR, SUBUNIT, AND INDUCTION. STRAIN=N3H; PubMed=12094731 [NCBI, ExPASy, EBI, Israel, Japan] Zamocky M., Polek B., Godocikova J., Koller F.; "Oxidative stress-induced expression of catalases in Comamonas terrigena."; Folia Microbiol. (Praha) 47:235-240(2002).

Comments

FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group.
BIOPHYSICOCHEMICAL PROPERTIES:

pH dependence: Active from pH 6.0 to 10.0;
Temperature dependence: Activity decreases at temperatures above 55 degrees Celsius;
SUBUNIT: Homodimer.
INDUCTION: Constitutively expressed. Inducible by oxidative stress in the exponential phase of bacterial growth.
MASS SPECTROMETRY: Mass=55417; Method=MALDI; Range=1-?; Source=PubMed:15177292;.
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

Protein family/group databases

4280; CterKat01.

Ontologies

GO:0042542;	Biological process: response to hydrogen peroxide (inferred from direct assay from UniProtKB).
QuickGo view.

Family and domain databases

PS00437; CATALASE_1; PARTIAL.
PS00438; CATALASE_2; PARTIAL.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 >57`	`>57`	`Catalase-1.`	`PRO_0000084984`
`METAL`	`37 37`		`Iron (heme axial ligand) (By similarity).`
`NON_CONS`	`13 14`
`NON_CONS`	`32 33`
`NON_CONS`	`42 43`
`NON_TER`	`57 57`

Sequence information

Length: 57 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 6099 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 22AC1B93B4F3D72E [This is a checksum on the sequence]

        10         20         30         40         50 
THCLTTAAGA PVARFSTVAG ERGAADAERD IRRLFSYGDA ARRLGVNHQH IPVNAPR

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools