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UniProtKB/Swiss-Prot entry P84155


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM6_LEIMA
Primary accession number P84155
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on September 13, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name Coproporphyrinogen III oxidase
Synonyms Coproporphyrinogenase
Coprogen oxidase
EC 1.3.3.3
Gene name
ORFNames: LMAJ006828, LmjF06.1270
From
Leishmania major [TaxID: 5664] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MHOM/IL/81/Friedlin;
DOI=10.1126/science.1112680; PubMed=16020728 [NCBI, ExPASy, EBI, Israel, Japan]
Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.;
"The genome of the kinetoplastid parasite, Leishmania major.";
Science 309:436-442(2005).
[2]
X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
Structural genomics of pathogenic protozoa consortium (SGPP);
Submitted (MAR-2004) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CT005245; CAJ02175.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_001680900.1; -.
3D structure databases
PDB
1VJU; X-ray; 1.40 A; A/B=1-301.[ExPASy / RCSB / EBI]
2QT8; X-ray; 1.75 A; A/B=1-301.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1VJU; -.
2QT8; -.
ModBase P84155.
Family and domain databases
InterPro IPR001260; Coprogen_oxidas.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1500.10; Coprogen_oxidas; 1.
PANTHER PTHR10755; Coprogen_oxidas; 1.
Pfam PF01218; Coprogen_oxidas; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000166; Coproporphyri_ox; 1.
PRINTS PR00073; COPRGNOXDASE.
PROSITE PS01021; COPROGEN_OXIDASE; 1.
BLOCKS P84155.
Genome annotation databases
GeneID 5649152; -.
KEGG lma:LmjF06.1270; -.
Phylogenomic databases
HOGENOM P84155; -.
Other
ProtoNet P84155.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Heme biosynthesis; Oxidoreductase; Porphyrin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   301  301     Coproporphyrinogen III oxidase. PRO_0000109876
HELIX   2    27  26      
STRAND   33    39  7      
TURN   40    42  3      
STRAND   43    52  10      
STRAND   54    69  16      
STRAND   86   100  15      
STRAND   105   117  13      
STRAND   120   133  14      
HELIX   139   153  15      
HELIX   154   156  3      
HELIX   160   171  12      
STRAND   172   174  3      
HELIX   175   177  3      
STRAND   179   191  13      
HELIX   196   221  26      
HELIX   228   247  20      
HELIX   250   257  8      
HELIX   262   265  4      
HELIX   266   268  3      
HELIX   286   292  7      
HELIX   294   297  4      
Sequence information
Length: 301 AA [This is the length of the unprocessed precursor] Molecular weight: 34370 Da [This is the MW of the unprocessed precursor] CRC64: A5D8CFE90BA90435 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSLAVEAVKD FLLKLQDDIC EALEAEDGQA TFVEDKWTRE GGGGGRTRVM VDGAVIEKGG 

        70         80         90        100        110        120 
VNFSHVYGKG LPMSSTERHP DIAGCNFEAM GVSLVIHPKN PHVPTSHANV RLFVAEREGK 

       130        140        150        160        170        180 
EPVWWFGGGF DLTPYYAVEE DCRDFHQVAQ DLCKPFGADV YARFKGWCDE YFFIPYRNEA 

       190        200        210        220        230        240 
RGIGGLFFDD LNEWPFEKCF EFVQAVGKGY MDAYIPIVNR RKNTPYTEQQ VEFQEFRRGR 

       250        260        270        280        290        300 
YAEFNLVIDR GTKFGLQSGG RTESILISLP PRARWGYNWQ PEPGTPEARL TEYFLTKRQW 


V 

P84155 in FASTA format

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