[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 19364 / DSM 1382 / NCIB 9332 / VKM B-1759; Hipp W.M., Trueper H.G.; Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the reduction of sulfite to sulfide. This is the terminal oxidation reaction in sulfate respiration, a process catalyzed by the sulfate-reducing bacteria.
CATALYTIC ACTIVITY: (O₃S.S.SO₃)^2- + acceptor + 2 H₂O + OH^- = 3 HSO₃^- + reduced acceptor.
COFACTOR: Binds 1 4Fe-4S cluster per subunit (By similarity).
COFACTOR: Binds 2 sirohemes per subunit (By similarity).
SUBUNIT: Heterohexamer of two alpha, two beta and two gamma subunits.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U80961; AAB41001.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P94693.

Ontologies

GO:0018551;	Molecular function: hydrogensulfite reductase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006067; Nir_Sir_4Fe4S.
Graphical view of domain structure.

Pfam

PF01077; NIR_SIR; 1.
Pfam graphical view of domain structure.

PROSITE

PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Heme; Iron; Iron-sulfur; Metal-binding; Oxidoreductase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`<1 198`	`>198`	`Sulfite reductase, dissimilatory-type subunit alpha.`	`PRO_0000080029`
`DOMAIN`	`55 83`	`29`	`4Fe-4S ferredoxin-type.`
`METAL`	`45 45`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`64 64`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`67 67`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`70 70`		`Iron-sulfur (4Fe-4S) (Potential).`
`NON_TER`	`1 1`

Sequence information

Length: 198 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 22384 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 92B9643231A98AE4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
WKDDIKIDQE AVKAYVGGEF KPNAGAHAGR DWGKFDIEAE VVGLCPTGCM TYESGTLSID 

        70         80         90        100        110        120 
NKNCTRCMHC INTMPRALKI GDERGASILV GAKAPVLDGA QMGSLLIPFI AAEEPFDEVK 

       130        140        150        160        170        180 
EVIENIWEWW MEEGKNRERL GETMKRVGFQ KLLEVTGTKA VPQHVSEPRH NPYIFFKEEE 

       190 
VPGGWSRDIS DYRKRHMR

P94693 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools